Prevalence of Helicobacter pylori in patients with nasal polyps: A preliminary report

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dc.contributor.authorKoc, C
dc.contributor.authorArikan, OK
dc.contributor.authorAtasoy, P
dc.contributor.authorAksoy, A
dc.date.accessioned2020-06-25T17:35:50Z
dc.date.available2020-06-25T17:35:50Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: The aim of the study is to determine the presence of H. pylori in nasal polyps by both immunohistochemical staining with H. pylori antibody of biopsy specimens and enzyme-linked immunoadsorbent assay (ELISA) of sera. Study Design: A prospective, controlled, clinical trial. Methods: We enrolled 30 patients with nasal polyps and 20 controls with middle concha bullosa undergoing endoscopic sinus surgery (ESS). Blood samples of both the study and control groups were evaluated for anti-H. pylori specific immunoglobulin (Ig)G antibodies by ELISA. In addition, biopsy specimens of the removed polyps and the mucosal part of middle conchas were examined by the immunohistochemical analysis with H. pylori antibody. Results: In the blood samples, specific IgG antibodies to H. pylori were found in 26 (86.7%) of 30 polyp patients and 17 (85%) of 20 controls. In 6 (20%) of the 30 patients, H. pylori was identified in the nasal polyp tissue, but it was not detected in the mucosal part of the middle concha specimens. No significant statistical difference was observed for H. pylori antibodies by ELISA among the patients with nasal polyps and the control group (Fisher's exact test, P = .59). However, there was a statistical difference between the polyp biopsy specimens and the control biopsy specimens by immunohistochemical staining (Fisher's exact test, P = .037). Conclusions: This study indicates that H. pylori was found in increased prevalence in the nasal polyps. However, further controlled epidemiologic studies would be necessary to confirm our results and clarify the potential underlying pathogenetic mechanisms.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/01.mlg.0000147924.96980.34
dc.identifier.endpage1944en_US
dc.identifier.issn0023-852X
dc.identifier.issn1531-4995
dc.identifier.issue11en_US
dc.identifier.pmid15510018
dc.identifier.scopus2-s2.0-9144271789
dc.identifier.scopusqualityQ1
dc.identifier.startpage1941en_US
dc.identifier.urihttps://doi.org/10.1097/01.mlg.0000147924.96980.34
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3222
dc.identifier.volume114en_US
dc.identifier.wosWOS:000225110300011
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofLaryngoscope
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHelicobacter pylorien_US
dc.subjectnasal polypen_US
dc.subjectimmunohistochemical stainingen_US
dc.subjectELISAen_US
dc.titlePrevalence of Helicobacter pylori in patients with nasal polyps: A preliminary reporten_US
dc.typeArticle

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