Markers of Endothelial Dysfunction and Evaluation of Vascular Reactivity Tests in Behcet Disease

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dc.contributor.authorOzuguz, Pinar
dc.contributor.authorKarabulut, Ayse Anil
dc.contributor.authorTulmac, Murat
dc.contributor.authorKisa, Ucler
dc.contributor.authorKocak, Mukadder
dc.contributor.authorGunduz, Ozgur
dc.date.accessioned2020-06-25T18:08:00Z
dc.date.available2020-06-25T18:08:00Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810; Gunduz, Ozgur/0000-0003-1021-5219;
dc.description.abstractWe assessed endothelial dysfunction (ED) in patients with Behcet disease (BD; n = 40) and healthy controls (n= 20). Serum lipid, homocysteine, asymmetric dimethylarginine (ADMA) and high-sensitivity C-reactive protein (hsCRP) levels, erythrocyte sedimentation rates (ESRs), and ultrasonographic flow-mediated dilatation (FMD) were measured. Mean hsCRP, ESR, homocysteine, and ADMA were significantly higher in the BD group (P <.001 for all). Patients with active BD had higher serum levels of hsCRP, homocysteine, and ESR compared with those in remission (P <.001, P <.001, and P =.005, respectively). Flow-mediated dilatation was significantly lower in patients with BD than in controls (P =.001). Flow-mediated dilatation correlated negatively with BD duration and serum ADMA levels (P <.001, r =-.745 and P <.001, r = -.682); a positive correlation was seen between serum ADMA levels and BD duration (P <.001, r =.552). Only stepwise multivariate regression analysis revealed BD duration to have a significant effect on FMD. Flow-mediated dilatation, in conjunction with markers of inflammation, may evaluate ED in patients with BD.en_US
dc.description.sponsorshipKirikkale University Research Project UnitKirikkale University [2008-16]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: Our study was supported by Kirikkale University Research Project Unit. The Project number: 2008-16.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1177/0003319713512413
dc.identifier.endpage943en_US
dc.identifier.issn0003-3197
dc.identifier.issn1940-1574
dc.identifier.issue10en_US
dc.identifier.pmid24277913
dc.identifier.scopus2-s2.0-84908893587
dc.identifier.scopusqualityQ2
dc.identifier.startpage937en_US
dc.identifier.urihttps://doi.org/10.1177/0003319713512413
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5707
dc.identifier.volume65en_US
dc.identifier.wosWOS:000346181200014
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Incen_US
dc.relation.ispartofAngiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet diseaseen_US
dc.subjectendothelial dysfunctionen_US
dc.subjecthigh-sensitivity C-reactive proteinen_US
dc.subjectasymmetric dimethylarginineen_US
dc.subjecthomocysteineen_US
dc.subjectflow-mediated dilatationen_US
dc.titleMarkers of Endothelial Dysfunction and Evaluation of Vascular Reactivity Tests in Behcet Diseaseen_US
dc.typeArticle

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