Human hepatocyte growth factor levels in patients undergoing thoracic operations
Yükleniyor...
Tarih
2006
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
European Respiratory Soc Journals Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Human hepatocyte growth factor (hHGF) is the most potent mitogen identified for alveolar type II cells, and may have other important functions in the repair of the alveolar epithelium and compensatory lung growth. A study was conducted to evaluate the changes of serum hHGF levels in patients who underwent thoracic surgical procedures. The patients comprised 17 males and 14 females with a mean age of 47.1 +/- 13.5 yrs, who underwent either lung resection (LR group) or nonlung resection (norLR group) thoracic procedures. The changes of hHGF levels were analysed in the pre- and post-operative periods in both groups. The pre-operative hHGF levels did not differ between the LR and the nonLR groups, which were 333.2 +/- 72.9 pg center dot mL(-1) and 343.6 +/- 125.3 pg center dot mL(-1), respectively. The hHGF levels in the LR group significantly increased up to 433.6 +/- 128.1 pg center dot mL(-1) and 430.8 +/- 128.2 pg center dot mL(-1) in post-operative days 1 and 3, respectively. However, the same levels in the nonLR group appeared as 333.2 +/- 77.0 pg center dot mL(-1) and 311.9 +/- 73.0 pg center dot mL(-1), respectively. In conclusion, the increases of serum human hepatocyte growth factor levels following pulmonary resection may imply the important role of human hepatocyte growth factor in lung regeneration or compensatory lung growth in humans.
Açıklama
KISA, Ucler/0000-0002-8131-6810
Anahtar Kelimeler
hepatocyte growth factor, pulmonary resection, surgery
Kaynak
European Respiratory Journal
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
27
Sayı
1
Künye
Dikmen, E., Kara, M., Kisa, U., Atinkaya, C., Han, S., & Sakinci, U. (2006). Human hepatocyte growth factor levels in patients undergoing thoracic operations. The European respiratory journal, 27(1), 73–76. https://doi.org/10.1183/09031936.06.00148704
