Significant elevation of serum soluble CD14 levels in patients with brucellosis
Yükleniyor...
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Natl Inst Infectious Diseases
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Activation of macrophages represents one of the initial events in innate immunity to intracellular infections. CD 14 is expressed principally by cells of monocyte/macrophage lineage and plays a pivotal role in innate recognition of bacterial cell wall components, particularly lipopolysaccharides. We measured serum concentrations of soluble CD14 (sCDl4) in serum samples obtained from 37 patients with brucellosis and 36 healthy controls. Serum levels of sCD14 were significantly increased in patients with brucellosis compared with those in healthy controls (P < 0.001). Re-analysis of serum samples after treatment in 25 patients demonstrated that treatment did not result in any significant decline in sCD14 levels. Despite a limited study population, these findings may implicate CD14 signaling as an important component of the initial anti-brucellar host response and suggest that activation of mononuclear phagocytic system is sustained even following effective treatment.
Açıklama
Birengel, Serhat/0000-0002-5599-6488
Anahtar Kelimeler
Kaynak
Japanese Journal Of Infectious Diseases
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
58
Sayı
1
Künye
closedAccess
