Significant elevation of serum soluble CD14 levels in patients with brucellosis

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dc.contributor.authorAyaşlıoğlu, Ergin
dc.contributor.authorTekeli, Emin
dc.contributor.authorBirengel, Serhat
dc.date.accessioned2020-06-25T17:40:46Z
dc.date.available2020-06-25T17:40:46Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.descriptionBirengel, Serhat/0000-0002-5599-6488
dc.description.abstractActivation of macrophages represents one of the initial events in innate immunity to intracellular infections. CD 14 is expressed principally by cells of monocyte/macrophage lineage and plays a pivotal role in innate recognition of bacterial cell wall components, particularly lipopolysaccharides. We measured serum concentrations of soluble CD14 (sCDl4) in serum samples obtained from 37 patients with brucellosis and 36 healthy controls. Serum levels of sCD14 were significantly increased in patients with brucellosis compared with those in healthy controls (P < 0.001). Re-analysis of serum samples after treatment in 25 patients demonstrated that treatment did not result in any significant decline in sCD14 levels. Despite a limited study population, these findings may implicate CD14 signaling as an important component of the initial anti-brucellar host response and suggest that activation of mononuclear phagocytic system is sustained even following effective treatment.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage14en_US
dc.identifier.issn1344-6304
dc.identifier.issn1884-2836
dc.identifier.issue1en_US
dc.identifier.pmid15728983
dc.identifier.scopus2-s2.0-15844403613
dc.identifier.scopusqualityQ2
dc.identifier.startpage11en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3545
dc.identifier.volume58en_US
dc.identifier.wosWOS:000227398900003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNatl Inst Infectious Diseasesen_US
dc.relation.ispartofJapanese Journal Of Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleSignificant elevation of serum soluble CD14 levels in patients with brucellosisen_US
dc.typeArticle

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