The effects of hormone therapy, estrogen therapy and tibolone on apoptosis and cyclin D-1 expression in postmenopausal vaginal epithelium
Yükleniyor...
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Bv
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To investigate the effects of hormone therapy, estrogen therapy and tibolone on markers of apoptosis including bcl-2, and bax and cyclin D, expression in postmenopausal vaginal epithelium. Study design: Thirty postmenopausal women were randomized to the treatment protocols (0.625 mg conjugated equine estrogen (CEE) + 2.5 mg medroxyprogesterone acetate (MPA); 2 mg estradiol valerate; 2.5 mg tibolone). After baseline vaginal biopsy, control biopsies were performed after 70 days following the initiation of the therapy. Bcl-2, bax, Bcl-2/bax ratio, cyclin D, measurements were performed immunohistochemically. Data were analyzed by Kruskal-Wallis, Mann-Whitney U and Wilcoxon tests. Results: After the treatment period the above-mentioned parameters were not different among the groups except for cyclin D-1 levels. Cyclin D-1 expression was found to be strong in patients with treated estradiol valerate. Conclusions: The effects of estrogen on cyclin D-1 expression were not detected with tibolone or with the addition of progesterone to estrogen in the vaginal epithelium. Cyclin D, appeared to have stronger effects on the estrogen related proliferation compared to apoptotic markers in vaginal epithelial cells. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
Açıklama
Yucel, Aykan/0000-0002-5888-692X
Anahtar Kelimeler
vagina, hormone therapy, tibolone, apoptosis, cyclin D-1, Bcl-2, bax
Kaynak
European Journal Of Obstetrics & Gynecology And Reproductive Biology
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
121
Sayı
1
Künye
closedAccess
