The effects of hormone therapy, estrogen therapy and tibolone on apoptosis and cyclin D-1 expression in postmenopausal vaginal epithelium

Basit Öğe Kaydı
dc.contributor.authorSağsöz, Nevin
dc.contributor.authorYücel, Aykan
dc.contributor.authorNoyan, Volkan
dc.contributor.authorBozdoğan, Önder
dc.date.accessioned2020-06-25T17:40:32Z
dc.date.available2020-06-25T17:40:32Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.descriptionYucel, Aykan/0000-0002-5888-692X
dc.description.abstractObjective: To investigate the effects of hormone therapy, estrogen therapy and tibolone on markers of apoptosis including bcl-2, and bax and cyclin D, expression in postmenopausal vaginal epithelium. Study design: Thirty postmenopausal women were randomized to the treatment protocols (0.625 mg conjugated equine estrogen (CEE) + 2.5 mg medroxyprogesterone acetate (MPA); 2 mg estradiol valerate; 2.5 mg tibolone). After baseline vaginal biopsy, control biopsies were performed after 70 days following the initiation of the therapy. Bcl-2, bax, Bcl-2/bax ratio, cyclin D, measurements were performed immunohistochemically. Data were analyzed by Kruskal-Wallis, Mann-Whitney U and Wilcoxon tests. Results: After the treatment period the above-mentioned parameters were not different among the groups except for cyclin D-1 levels. Cyclin D-1 expression was found to be strong in patients with treated estradiol valerate. Conclusions: The effects of estrogen on cyclin D-1 expression were not detected with tibolone or with the addition of progesterone to estrogen in the vaginal epithelium. Cyclin D, appeared to have stronger effects on the estrogen related proliferation compared to apoptotic markers in vaginal epithelial cells. (c) 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.ejogrb.2004.11.029
dc.identifier.endpage66en_US
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.issue1en_US
dc.identifier.pmid15955616
dc.identifier.scopus2-s2.0-21244457890
dc.identifier.scopusqualityQ2
dc.identifier.startpage61en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2004.11.029
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3478
dc.identifier.volume121en_US
dc.identifier.wosWOS:000230704500011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal Of Obstetrics & Gynecology And Reproductive Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectvaginaen_US
dc.subjecthormone therapyen_US
dc.subjecttiboloneen_US
dc.subjectapoptosisen_US
dc.subjectcyclin D-1en_US
dc.subjectBcl-2en_US
dc.subjectbaxen_US
dc.titleThe effects of hormone therapy, estrogen therapy and tibolone on apoptosis and cyclin D-1 expression in postmenopausal vaginal epitheliumen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
The effects of hormone therapy, estrogen therapy and tibolone on apoptosis and cyclin D-1 expression in postmenopausal vaginal epithelium.pdf
Boyut:
285.97 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu

Kişisel bilgilerinizi şu amaçlarla toplar ve işleriz: Kimlik Doğrulama, Tercihler, Onay ve İstatistikler.
Daha fazla bilgi edinmek için lütfen gizlilik politikası sayfamızı okuyun.

Özelleştirme