Effects of basic fibroblast growth factor and phenytoin on healing of abdominal wall fascia and colonic anastomoses
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Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Int College Of Surgeons
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to investigate the effects of basic fibroblast growth factor (bFGF) and phenytoin on wound healing in rats compromised by methylprednisone. This study was conducted in four groups consisting of 20 male Wistar rats. Rats in groups 2, 3, and 4 had a daily injection of methylprednisolone 5 mg/kg/day for 15 days. Laparotomy and sigmoid transsection were performed on day 15. In the postoperative period, rats in group 1 received no medication, group 2 received methylprednisolone 5 mg/kg/day intramuscularly, group 3 received bFGF 5 mu g/kg on days 1-3 subcutaneously, and group 4 received phenytoin 40 mg/kg/day intraperitoneally. bFGF and phenytoin had a positive effect on tensile strength, hydroxyproline content, and wound healing parameters in abdominal wall fascia. In colonic anastomosis, phenytoin corrected all parameters, but bFGF had no effect.
Açıklama
Anahtar Kelimeler
basic fibroblast growth factor, phenytoin, fascial healing, anastomotic healing
Kaynak
International Surgery
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
91
Sayı
3
Künye
closedAccess
