Effects of basic fibroblast growth factor and phenytoin on healing of abdominal wall fascia and colonic anastomoses

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dc.contributor.authorGüneş, Hayrettin Varol
dc.contributor.authorDemirer, Seher
dc.contributor.authorAydinuraz, Kuzey
dc.contributor.authorKepenekci, Ilknur
dc.contributor.authorKuterdem, Ercüment
dc.contributor.authorAribal, Dikmen
dc.date.accessioned2020-06-25T17:43:33Z
dc.date.available2020-06-25T17:43:33Z
dc.date.issued2006
dc.description.abstractThe aim of this study was to investigate the effects of basic fibroblast growth factor (bFGF) and phenytoin on wound healing in rats compromised by methylprednisone. This study was conducted in four groups consisting of 20 male Wistar rats. Rats in groups 2, 3, and 4 had a daily injection of methylprednisolone 5 mg/kg/day for 15 days. Laparotomy and sigmoid transsection were performed on day 15. In the postoperative period, rats in group 1 received no medication, group 2 received methylprednisolone 5 mg/kg/day intramuscularly, group 3 received bFGF 5 mu g/kg on days 1-3 subcutaneously, and group 4 received phenytoin 40 mg/kg/day intraperitoneally. bFGF and phenytoin had a positive effect on tensile strength, hydroxyproline content, and wound healing parameters in abdominal wall fascia. In colonic anastomosis, phenytoin corrected all parameters, but bFGF had no effect.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage156en_US
dc.identifier.issn0020-8868
dc.identifier.issue3en_US
dc.identifier.pmid16845856
dc.identifier.scopus2-s2.0-33750846666
dc.identifier.scopusqualityQ4
dc.identifier.startpage151en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3796
dc.identifier.volume91en_US
dc.identifier.wosWOS:000238370600005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInt College Of Surgeonsen_US
dc.relation.ispartofInternational Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbasic fibroblast growth factoren_US
dc.subjectphenytoinen_US
dc.subjectfascial healingen_US
dc.subjectanastomotic healingen_US
dc.titleEffects of basic fibroblast growth factor and phenytoin on healing of abdominal wall fascia and colonic anastomosesen_US
dc.typeArticle

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