Influence of scaffold composition over invitro osteogenic differentiation of hBMSCs and invivo inflammatory response

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dc.contributor.authorCosta-Pinto, Ana R.
dc.contributor.authorVargel, I.
dc.contributor.authorTuzlakoglu, K.
dc.contributor.authorCorrelo, V. M.
dc.contributor.authorSol, P. C.
dc.contributor.authorFaria, S.
dc.contributor.authorNeves, Nuno M.
dc.date.accessioned2020-06-25T18:12:14Z
dc.date.available2020-06-25T18:12:14Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionBayram, Cem/0000-0001-8717-4668; Faria, Susana/0000-0001-8014-9902; Correlo, Vitor M/0000-0002-5516-7583; Neves, Nuno M/0000-0003-3041-0687; Reis, Rui L. L/0000-0002-4295-6129; Sol, Paula/0000-0003-0512-0928; Costa-Pinto, Ana Rita/0000-0002-4764-8539; UMinho, 3B's Research Group/0000-0002-5195-3456; Tuzlakoglu, Kadriye/0000-0002-7564-9213
dc.description.abstractTo understand the role of chitosan in chitosan-poly(butylene succinate) scaffolds (50% wt), 50%, 25%, and 0% of chitosan were used to produce different scaffolds. These scaffolds were invitro seeded and cultured with human bone marrow stromal cells in osteogenic conditions, revealing that higher percentage of chitosan showed enhanced cell viability over time, adhesion, proliferation, and osteogenic differentiation. Scaffolds were also implanted in cranial defects and iliac submuscular region in Wistar rats, and the results evidenced that chitosan-containing scaffolds displayed mild inflammatory response and good integration with surrounding tissues, showed by connective tissue colonization and the presence of new blood vessels. Scaffolds without chitosan-evidenced necrotic tissue in scaffolds' interior, proving that chitosan exerts a positive effect over cell behavior and displays a milder host inflammatory response invivo.en_US
dc.description.sponsorshipEuropean Network of Excellence EXPERTISSUES [NMP3-CT-2004-500283]; Maxbone FCT [PTDC/SAU-ENB/115179/2009]; Portuguese research council "Fundacao para a Ciencia e a Tecnologia" (FCT)Portuguese Foundation for Science and Technology [SFRH/24735/2005]en_US
dc.description.sponsorshipThis work was partially supported by the European Network of Excellence EXPERTISSUES (NMP3-CT-2004-500283) and Maxbone FCT funded project (PTDC/SAU-ENB/115179/2009). Ana Costa-Pinto was supported by the scholarship SFRH/24735/2005 from the Portuguese research council "Fundacao para a Ciencia e a Tecnologia" (FCT).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1177/0885328213512385
dc.identifier.endpage1442en_US
dc.identifier.issn0885-3282
dc.identifier.issn1530-8022
dc.identifier.issue9en_US
dc.identifier.pmid24255003
dc.identifier.scopus2-s2.0-84898975588
dc.identifier.scopusqualityQ2
dc.identifier.startpage1430en_US
dc.identifier.urihttps://doi.org/10.1177/0885328213512385
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5826
dc.identifier.volume28en_US
dc.identifier.wosWOS:000334636700014
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal Of Biomaterials Applications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiomaterialsen_US
dc.subjecttissue engineeringen_US
dc.subjectregenerative medicineen_US
dc.subjectChitosanen_US
dc.subjectscaffoldsen_US
dc.titleInfluence of scaffold composition over invitro osteogenic differentiation of hBMSCs and invivo inflammatory responseen_US
dc.typeArticle

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