Immunohistochemical investigation of cerebellum in dogs infected with canine distemper virus

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dc.contributor.authorKabakci, N
dc.contributor.authorYarim, M
dc.contributor.authorKarahan, S
dc.contributor.authorGuvenc, T
dc.contributor.authorYagci, BB
dc.contributor.authorGurcan, IS
dc.date.accessioned2020-06-25T17:40:12Z
dc.date.available2020-06-25T17:40:12Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.descriptionGuvenc, Tolga/0000-0003-1468-3415; /0000-0002-0636-4214
dc.description.abstractThe cerebella of 21 dogs with canine distemper virus (CDV) infection and four normal dogs were examined histopathologically and immunohistochemically. Cerebella of CDV-infected dogs showed nonsuppurative demyelinating encephalomyelitis, classified as acute, subacute or chronic. Immunolocalisation of CDV antigen also confirmed the infection. Tissues were examined for co-localisation of the CDV antigen with either an astrocyte-specific marker, glial fibrillary acidic protein (GFAP), or an oligodendrocyte-specific marker, galactocerebroside (GalC). Immunoreactive cells were counted in demyelinating areas of the white matter. The number of astrocytes (GFAP positive) was significantly (p < 0.05) higher in CDV-infected dogs compared to controls. In contrast, the number of oligodendrocytes (GalC positive) was significantly (p < 0.001) lower in CDV-infected dogs and was much lower in chronic cases (p < 0.05). Approximately 41% of astrocytes and 17% of oligodendrocytes were immunoreactive for CDV. The ratio of CDV-infected oligodendrocytes and astrocytes remained almost constant during the progression of the disease (P > 0.05). In conclusion, CDV infects both astrocytes and oligodendrocytes. The gradual loss of oligodendrocytes is most likely responsible for the progressive demyelination in CDV infection. Astrocytosis in CDV infection should be further investigated if it occurs to stimulate oligodendrocytes for myelin production to compensate for the loss or to induce oligodendrocyte degeneration.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage337en_US
dc.identifier.issn0236-6290
dc.identifier.issue3en_US
dc.identifier.pmid15379447
dc.identifier.scopus2-s2.0-4143080737
dc.identifier.scopusqualityQ2
dc.identifier.startpage327en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3338
dc.identifier.volume52en_US
dc.identifier.wosWOS:000223407400009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAkademiai Kiadoen_US
dc.relation.ispartofActa Veterinaria Hungarica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcerebellumen_US
dc.subjectcanine distemper virusen_US
dc.subjectglial fibrillary acidic proteinen_US
dc.subjectgalactocerebrosideen_US
dc.subjectimmunohistochemistryen_US
dc.titleImmunohistochemical investigation of cerebellum in dogs infected with canine distemper virusen_US
dc.typeArticle

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