Evidence of chronic Chlamydia pneumoniae infection in patients with Behcet's disease

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dc.contributor.authorAyaslioglu, E
dc.contributor.authorDuzgun, N
dc.contributor.authorErkek, E
dc.contributor.authorInal, A
dc.date.accessioned2020-06-25T17:40:06Z
dc.date.available2020-06-25T17:40:06Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.descriptionOzturk Durmaz, Emel/0000-0003-0661-9720
dc.description.abstractBehcet's disease is a chronic vasculitis of unknown aetiology. Particular viral and bacterial pathogens have long been suspected of playing a role in the pathogenesis of the disease. Chlamydia pneumoniae is an intracellular bacterium capable of causing chronic infections. Some reports have suggested that the microorganism might be involved in the pathogenesis of vasculitis. The purpose of the present study was to investigate a possible correlation between C. pneumoniae infection and Behcet's disease. For this purpose, 90 consecutive patients with Behcet's disease and 50 healthy controls were enrolled. Immunoglobulin A (IgA) and IgG antibodies to C. pneumoniae were determined by 2 different techniques, namely indirect fluorescent antibody assay (IFA) and enzyme linked immunosorbent assay (ELISA). IgA antibodies to C. pneumoniae were detected in 17 (18.9%) patients with Behcet's disease and in 1 (2%) healthy control by IFA. By ELISA 27 patients (30.0%) and 6 controls (12.0%) had C. pneumoniae IgA. A significant difference was observed for IgA seropositivity between the 2 groups. Although IgG seropositivity between the 2 groups did not differ significantly, the number of individuals with IgG titres of greater than or equal to 1: 1000 was significantly higher in the patient group (43.1%) compared with the control group (13.9%). These finding provide serological evidence of chronic C. pneumoniae infection in association with Behcet's disease.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/00365540410020730
dc.identifier.endpage430en_US
dc.identifier.issn0036-5548
dc.identifier.issn1651-1980
dc.identifier.issue6-7en_US
dc.identifier.pmid15307562
dc.identifier.scopus2-s2.0-4143149601
dc.identifier.scopusqualityN/A
dc.identifier.startpage428en_US
dc.identifier.urihttps://doi.org/10.1080/00365540410020730
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3275
dc.identifier.volume36en_US
dc.identifier.wosWOS:000222351100005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInforma Healthcareen_US
dc.relation.ispartofScandinavian Journal Of Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEvidence of chronic Chlamydia pneumoniae infection in patients with Behcet's diseaseen_US
dc.typeArticle

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