Antiparasitic efficiency of Artemisia absinthium on Toxocara cati in naturally infected cats
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Dosyalar
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada Toxocara cati ile doğal enfekte kedilere Artemisia absinthum ekstresinin etkinliğini ile in vitro ortamda T.cati yumurtasındaki embriyonik gelişime etkisinin belirlenmesi amaçlanmıştır. Yöntemler: Artemisia absinthum ekstresi kedilere 300 mg/kg (Grup 1) ve 600 mg/kg (Grup 2) dozda ağızdan verilmiştir. Ekstre günde bir kez olacak biçimde 7 gün süreyle uygulanmıştır. Kedilerin dışkıları tedavi öncesinde, tedavi esnasında ve tedavi sonrasında makroskobik ve doymuş tuzlu su fl otasyon yöntemi ile mikroskobik olarak incelenmiştir. Ekstre verilmesi bittikten sonraki 8 gün süreyle dışkı incelenmiştir. Dışkı yumurta sayısındaki değişim McMaster tekniği kullanılarak belirlenmiştir. Bulgular: Deneme gruplarındaki kedilerde gram dışkıdaki yumurta sayısının dereceli olarak azaldığı gözlenmiştir. Tedavi esnasında kedilerde ALT, AST, ALP, üre ve kreatinin aktivitelerinin fi zyolojik değerler arasında olduğu belirlenmiştir. A.abstinhum ile yapılan in vitro denemelerde tüm gruplarda (tedavi ve kontrol) T.cati yumurtaları içindeki embriyonik gelişimin benzer olduğu gözlenmiştir. A.absinthum ekstresi in vitro ortamda larva gelişimini engellemediği belirlenmiştir. Sonuç: Bu bitki ekstresi gelecekte parazit hastalıkalrının tedavisi için bir alternatif olabilir.
Objective: The first aim of the present study was to determine the effi ciency of A. absinthium extract on cats naturally infected with Toxocara cati. The second aim was to determine the effi ciency of the extract on the embryonic development of T. cati eggs in vitro. Methods: Artemisia absinthium extract was orally administrated to cats at the doses of 300 mg/kg and 600 mg/kg body weight in Group 1 and 2, respectively. It was given only once a day and the treatment continued 7 consecutive days. The faeces of the cats were examined both macroscopically and microscopically by fl otation procedure with saturated salt solution pre-, during and post- treatment period. The faecal analysis was maintained during 8 days after completing the extract administration. The alteration of faecal egg numbers was performed by using the McMaster technique. Results: The faecal egg numbers per gram were decreased gradually in cats in the trial groups. In the treatment period, the activities of ALT, AST, ALP, urea and creatinine were located within the physiological ranges in cats. In in vitro trials with A. absinthium extract, the embryonic development of T. cati eggs was identical in all groups (treatment and control). A. absinthium extract did not inhibit larval development in eggs in in vitro trials. Conclusion: This plant extract may be an alternative choice in the treatment of parasitic diseases in future.
Objective: The first aim of the present study was to determine the effi ciency of A. absinthium extract on cats naturally infected with Toxocara cati. The second aim was to determine the effi ciency of the extract on the embryonic development of T. cati eggs in vitro. Methods: Artemisia absinthium extract was orally administrated to cats at the doses of 300 mg/kg and 600 mg/kg body weight in Group 1 and 2, respectively. It was given only once a day and the treatment continued 7 consecutive days. The faeces of the cats were examined both macroscopically and microscopically by fl otation procedure with saturated salt solution pre-, during and post- treatment period. The faecal analysis was maintained during 8 days after completing the extract administration. The alteration of faecal egg numbers was performed by using the McMaster technique. Results: The faecal egg numbers per gram were decreased gradually in cats in the trial groups. In the treatment period, the activities of ALT, AST, ALP, urea and creatinine were located within the physiological ranges in cats. In in vitro trials with A. absinthium extract, the embryonic development of T. cati eggs was identical in all groups (treatment and control). A. absinthium extract did not inhibit larval development in eggs in in vitro trials. Conclusion: This plant extract may be an alternative choice in the treatment of parasitic diseases in future.
Açıklama
Anahtar Kelimeler
Parazitoloji, Genel ve Dahili Tıp
Kaynak
Türkiye Parazitoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
35
Sayı
1
Künye
Yıldız, K., Başalan, M., Duru, Ö., Gökpınar, S. (2011). Antiparasitic efficiency of Artemisia absinthium on Toxocara cati in naturally infected cats. Türkiye Parazitoloji Dergisi, 35(1), 10 - 14.
