The Effect of Hypothermia on Splanchnic Flows and Lung in a Two-Hit Hemorrhagic Shock Model

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dc.contributor.authorDeniz, Turgut
dc.contributor.authorAgalar, Canan
dc.contributor.authorAgalar, Fatih
dc.contributor.authorComu, Faruk M.
dc.contributor.authorCaglayan, Osman
dc.contributor.authorAlpay, Yesim
dc.contributor.authorSaygun, Oral
dc.date.accessioned2020-06-25T17:51:26Z
dc.date.available2020-06-25T17:51:26Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground. To evaluate the effect of hypothermia on bacterial translocation, splanchnic vascular flow, lung tissue weight, and levels of malondialdehyde (MDA) and nitric oxide (NO) in a two-hit model of hemorrhagic shock. Methods. Thirty rats were randomly allocated into three groups of 10 rats each. In the control group (group C), rats were treated without hemorrhage, and normothermia (37 degrees C) was maintained. In the mild hypothermia group (group MH), rats were subjected to volume-controlled hemorrhage (2 mL/100g) and a rectal temperature of 34 degrees C was maintained. In the normothermic group (group NT), rats were treated as in group MH, except for hypothermia. Seventy-two hours after hemorrhagic shock (first insult), Pseudomonas aeuruginosa was administered intratracheally as a second insult. Finally, mesenteric vascular flow patterns were recorded. Bacterial translocation was studied from tissue samples of spleen, liver, and mesenteric lymph nodes. Blood samples were obtained to evaluate the possible presence of bacteria in the bloodstream. Lung tissue weight ratio, MDA, and NO levels in lung tissue were assessed. Results. Renal, mesenteric, and portal venous flow rates were found to be lower in groups Mill and NT in comparison with group C. Blood flow profiles were lower in group NT than in group MH (P < 0.05). Bacterial translocation was not observed in group C, and it was detected more often in group NT than in group MH. Lung weight ratio was found to be higher in group NT compared with groups MH and C. Although it did not reach the level of statistical significance, MDA level in the control group was lower than that in the NT group (P = 0.085). Conclusion. Hypothermia corrected mesenteric blood flow and decreased the occurrence of bacterial translocation in the two-hit model of hemorrhagic shock and tracheal inoculaton of P. aeruginosa (C) 2010 Elsevier Inc. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.jss.2008.08.029
dc.identifier.endpage126en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue1en_US
dc.identifier.pmid19541326
dc.identifier.scopus2-s2.0-71649101236
dc.identifier.scopusqualityQ1
dc.identifier.startpage121en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2008.08.029
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4862
dc.identifier.volume158en_US
dc.identifier.wosWOS:000276650000019
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal Of Surgical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthemorrhagic shocken_US
dc.subjecthypothermiaen_US
dc.subjecttraumaen_US
dc.subjectraten_US
dc.subjecttwo-hit modelen_US
dc.titleThe Effect of Hypothermia on Splanchnic Flows and Lung in a Two-Hit Hemorrhagic Shock Modelen_US
dc.typeArticle

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