The Investigation of the Cox-2 Selective Inhibitor Parecoxib Effects in Spinal Cord Injury in Rat

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dc.contributor.authorYuksel, Ulas
dc.contributor.authorBakar, Bulent
dc.contributor.authorDincel, Gungor Cagdas
dc.contributor.authorYildiran, Fatma Azize Budak
dc.contributor.authorOgden, Mustafa
dc.contributor.authorKisa, Ucler
dc.date.accessioned2020-06-25T18:34:00Z
dc.date.available2020-06-25T18:34:00Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionYILDIRAN, Fatma Azize BUDAK/0000-0001-7031-6834; DINCEL, Gungor Cagdas/0000-0002-6985-3197; KISA, Ucler/0000-0002-8131-6810
dc.description.abstractAim: Today, spinal cord injury (SCI) can be rehabilitated but cannot be treated adequately. This experimental study was conducted to investigate possible beneficial effects of methylprednisolone and parecoxib in treatment of SCI. Materials and methods: Forty-eight male Wistar albino rats were assigned into CONTROL, acute (MP-A, PX-A, and PXMP-A), and subacute (MP-S, PX-S, and PXMP-S) stage groups. Then, to induce SCI, a temporary aneurysm clip was applied to the spinal cord following T7-8 laminectomy, except in the CONTROL group. Four hours later parecoxib, methylprednisolone, or their combination was administered to rats intraperitoneally except CONTROL, SHAM-A, and SHAM-S groups. Rats in the acute stage group were sacrificed 72 h later, and whereas rats in the subacute stage were sacrificed 7 days later for histopathological and biochemical investigation and for gene-expression analyses. Results: Parecoxib and methylprednisolone and their combination could not improve histopathological grades in any stage. They also could not decrease malondialdehyde or caspase-3, myeloperoxidase levels in any stage. Parecoxib and methylprednisolone could decrease the TNF-alpha gene expression in subacute stage. Methylprednisolone could increase TGF-1 beta gene-expression level in acute stage. Conclusion: Neither of the experimental drugs, either alone or in combination, did not show any beneficial effects in SCI model in rats.en_US
dc.description.sponsorshipKirikkale University Scientific Research Project Coordination UnitKirikkale University [2014/076]en_US
dc.description.sponsorshipThis study was financially supported by Kirikkale University Scientific Research Project Coordination Unit (Project Number: 2014/076).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/08941939.2017.1423423
dc.identifier.endpage413en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue5en_US
dc.identifier.pmid29355394
dc.identifier.scopus2-s2.0-85041124192
dc.identifier.scopusqualityQ1
dc.identifier.startpage402en_US
dc.identifier.urihttps://doi.org/10.1080/08941939.2017.1423423
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7737
dc.identifier.volume32en_US
dc.identifier.wosWOS:000478887200003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Investigative Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcox-2 selective inhibitoren_US
dc.subjectmethylprednisoloneen_US
dc.subjectparecoxiben_US
dc.subjectraten_US
dc.subjectsecondary injuryen_US
dc.subjectspinal cord injuryen_US
dc.titleThe Investigation of the Cox-2 Selective Inhibitor Parecoxib Effects in Spinal Cord Injury in Raten_US
dc.typeArticle

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