Examination of Bcl-2, Bcl-X and bax protein expression in psoriasis

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dc.contributor.authorKoçak, M.
dc.contributor.authorBozdogan, O.
dc.contributor.authorErkek, E.
dc.contributor.authorAtasoy, P.
dc.contributor.authorBirol, A.
dc.date.accessioned2020-06-25T17:35:17Z
dc.date.available2020-06-25T17:35:17Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.descriptionOzturk Durmaz, Emel/0000-0003-0661-9720
dc.description.abstractBackground Psoriasis is an inflammatory skin disease characterized by epidermal hyperplasia and greatly accelerated epidermal turnover. The blockage of normal apoptotic process in the epidermis is one of the factors implicated in the pathogenesis of psoriasis. Objective The purpose of the present study was to elucidate whether bcl-family proteins are significantly involved in the hypothetical antiapoptotic cascade in lesional psoriatic epidermis. Methods Twenty-six lesional biopsy samples of 26 patients with psoriasis and five control specimens from normal skin were studied by immunohistochemical method for the differential expression of pro-apoptotic bax and antiapoptotic bcl-2 and bcl-x proteins. Results Compared with the normal epidermis, bcl-2 expression was significantly reduced, whereas bax and bcl-x were significantly overexpressed in the psoriatic epidermis. The localization of bcl-2/bax/bcl-x proteins in the psoriatic epidermis did not show a significant deviation from that in the normal epidermis. Conclusion These findings indicate a discordant expression of bcl-2 and bax/bcl-x in psoriatic epidermis. Increased bcl-x expression might contribute to the antiapoptotic response in psoriatic keratinocytes. The presence of strong bax expression with a concomitant decrease in bcl-2 expression suggests either a functional defect in bax protein or an inherent/acquired resistance to bax-mediated apoptosis in psoriatic keratinocytes.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1046/j.1365-4362.2003.01821.x
dc.identifier.endpage793en_US
dc.identifier.issn0011-9059
dc.identifier.issue10en_US
dc.identifier.pmid14521691
dc.identifier.scopus2-s2.0-20244380728
dc.identifier.scopusqualityQ1
dc.identifier.startpage789en_US
dc.identifier.urihttps://doi.org/10.1046/j.1365-4362.2003.01821.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3080
dc.identifier.volume42en_US
dc.identifier.wosWOS:000186078600003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofInternational Journal Of Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleExamination of Bcl-2, Bcl-X and bax protein expression in psoriasisen_US
dc.typeArticle

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