Seroprevalence of tetanus immunity among noninsulin-dependent diabetes mellitus patients

Basit Öğe Kaydı
dc.contributor.authorKilic, D.
dc.contributor.authorKaygusuz, S.
dc.contributor.authorSaygun, M.
dc.contributor.authorCakman, A.
dc.contributor.authorUzer, H.
dc.contributor.authorDoganci, L.
dc.date.accessioned2020-06-25T17:35:21Z
dc.date.available2020-06-25T17:35:21Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.description.abstractTetanus is a preventable disease that continues to affect people in both developing and developed countries. The aim of the present study was to evaluate the immunity profile to tetanus in patients with Type II diabetes mellitus (DM) and to compare them with healthy controls. The tetanus antitoxin levels in 310 diabetic patients (104 males and 206 females) and in 200 healthy controls (72 males and 128 females) were measured by ELISA (Virotech, Germany). The mean antitoxin concentration in patient and control groups were 0.8238+/-1.61 and 0.9978+/-1.49 IU/ml, respectively. There was a statistically significant difference between the two groups (z = -3.520, P = .0001 and odds ratio was 2.367). There was a definitive inverse correlation between the duration of diabetes and tetanus antibody titers (Spearman's correlation analysis, r = -.155, P = .006). A gender-dependent difference in the susceptibility to tetanus was present in the diabetic group with antibody titers being significantly higher in males compared with females (z = -2.267, P = .023). For both of control (chi(2) = 20.207, P = .003) and patient (chi(2) = 43.532, P = .0001) groups, there was a significant inverse correlation between the tetanus immunity levels and age. Statistically, a significant drop in antibody titers of both groups was found as the period past from the last immunization increased (Pearson correlation analysis: for patient group r = -.364, P = .0001; for control group r = -.143, P = .044). The tetanus antitoxin levels were significantly increased in individuals who had primary immunization during childhood (for patient group chi(2) = 17.191, P = .0001; for control group chi(2) = 9.911, P = .007). A significant reduction in the level of antitoxin immunity to tetanus in association with an increased susceptibility to infections in patients with diabetes may implicate the need for improving vaccination rates in this patient group. (C) 2003 Elsevier Inc. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/S1056-8727(02)00255-6
dc.identifier.endpage263en_US
dc.identifier.issn1056-8727
dc.identifier.issn1873-460X
dc.identifier.issue5en_US
dc.identifier.pmid12954154
dc.identifier.scopus2-s2.0-0042386053
dc.identifier.scopusqualityQ2
dc.identifier.startpage258en_US
dc.identifier.urihttps://doi.org/10.1016/S1056-8727(02)00255-6
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3098
dc.identifier.volume17en_US
dc.identifier.wosWOS:000188952300005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal Of Diabetes And Its Complications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiabetesen_US
dc.subjecttetanusen_US
dc.subjectseroprevalenceen_US
dc.titleSeroprevalence of tetanus immunity among noninsulin-dependent diabetes mellitus patientsen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Seroprevalence of tetanus immunity among noninsulin-dependent diabetes mellitus patients.pdf
Boyut:
140.85 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu