Thrombosis during all-trans-retinoic acid therapy in a child with acute promyelocytic leukemia and factor VQ 506 mutation
Yükleniyor...
Tarih
2000
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Acute promyelocytic leukemia (APL) is often associated with a severe hemostatic disorder, caused bg the release of procoagulant and fibrinolytic substances from leukemic blasts. The coagulation profile may exhibit disseminated intravascular coagulation and fibrinolysis or proteolysis. Therefore, heparin and antifibrinolytic agents alone or in combination have been used to prevent severe bleedings. Remission induction with all-trans-retinoic acid (ATRA) is accompanied with rapid correction of hemostatic abnormalities. Thrombosis is a rare complication of APL and may be due to the alterations in hemostasis caused by the disease itself as well as ATRA and antifibrinolytics. Here, the occurrence of thrombosis during induction treatment with ATRA combined with aprotinin and chemotherapy is described in a patient who is homozygous for factor VQ 506 mutation.
Açıklama
Anahtar Kelimeler
acute promyelocytic leukemia, all-trans-retinoic acid therapy, aprotinin, factor VQ 506 mutation, thrombosis
Kaynak
Pediatric Hematology And Oncology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
17
Sayı
2
Künye
closedAccess
