Thrombosis during all-trans-retinoic acid therapy in a child with acute promyelocytic leukemia and factor VQ 506 mutation

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dc.contributor.authorKocak, U
dc.contributor.authorGursel, T
dc.contributor.authorOzturk, G
dc.contributor.authorKantarci, S
dc.date.accessioned2020-06-25T17:34:44Z
dc.date.available2020-06-25T17:34:44Z
dc.date.issued2000
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAcute promyelocytic leukemia (APL) is often associated with a severe hemostatic disorder, caused bg the release of procoagulant and fibrinolytic substances from leukemic blasts. The coagulation profile may exhibit disseminated intravascular coagulation and fibrinolysis or proteolysis. Therefore, heparin and antifibrinolytic agents alone or in combination have been used to prevent severe bleedings. Remission induction with all-trans-retinoic acid (ATRA) is accompanied with rapid correction of hemostatic abnormalities. Thrombosis is a rare complication of APL and may be due to the alterations in hemostasis caused by the disease itself as well as ATRA and antifibrinolytics. Here, the occurrence of thrombosis during induction treatment with ATRA combined with aprotinin and chemotherapy is described in a patient who is homozygous for factor VQ 506 mutation.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/088800100276541
dc.identifier.endpage180en_US
dc.identifier.issn0888-0018
dc.identifier.issn1521-0669
dc.identifier.issue2en_US
dc.identifier.pmid10734661
dc.identifier.scopus2-s2.0-0342470558
dc.identifier.scopusqualityQ2
dc.identifier.startpage177en_US
dc.identifier.urihttps://doi.org/10.1080/088800100276541
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2865
dc.identifier.volume17en_US
dc.identifier.wosWOS:000085501700008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofPediatric Hematology And Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacute promyelocytic leukemiaen_US
dc.subjectall-trans-retinoic acid therapyen_US
dc.subjectaprotininen_US
dc.subjectfactor VQ 506 mutationen_US
dc.subjectthrombosisen_US
dc.titleThrombosis during all-trans-retinoic acid therapy in a child with acute promyelocytic leukemia and factor VQ 506 mutationen_US
dc.typeArticle

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