Neurosteroidogenesis in oligodendrocytes and Purkinje neurones of cerebellar cortex of dogs
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Tarih
2004
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Blackwell Verlag Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The cerebellum is a steroidogenic organ that expresses steroidogenic enzymes and produces neurosteroids. Purkinje neurones appear to be the most active steroidogenic cells in the cerebellar cortex. These neurones express 3beta-hydroxysteroid dehydrogenase (3beta-HSD), P450 side-chain cleavage (P450scc), 17alpha-hydroxylase/c17, 201yase (P450c17), P450 aromatase (P450arom) and produce pregnenolone, progesterone, dehydroepiandrosterone, androstenedion, oestradion and oestrone. Oligodendrocytes are predominantly the producer of myeline protein. The oligodendrocytes were identified by immunohistochemistry using a monoclonal antibody against myeline 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), a myeline specific enzyme. In this study we have examined the distribution of 3beta-HSD and CNPase by immunohistochemistry using monoclonal antibody in canine cerebellar cortex. The localization of oligodendrocytes within the cerebellar cortex was determined to be close to Purkinje neurones. This result suggests that endogenous progesterone synthesized de novo in the Purkinje neurone can promote myeline protein synthesis in oligodentrocytes.
Açıklama
/0000-0002-0636-4214
Anahtar Kelimeler
Kaynak
Anatomia Histologia Embryologia-Journal Of Veterinary Medicine Series C
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
33
Sayı
3
Künye
closedAccess
