Neurosteroidogenesis in oligodendrocytes and Purkinje neurones of cerebellar cortex of dogs

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dc.contributor.authorYarim, M
dc.contributor.authorKabakci, N
dc.date.accessioned2020-06-25T17:40:06Z
dc.date.available2020-06-25T17:40:06Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.description/0000-0002-0636-4214
dc.description.abstractThe cerebellum is a steroidogenic organ that expresses steroidogenic enzymes and produces neurosteroids. Purkinje neurones appear to be the most active steroidogenic cells in the cerebellar cortex. These neurones express 3beta-hydroxysteroid dehydrogenase (3beta-HSD), P450 side-chain cleavage (P450scc), 17alpha-hydroxylase/c17, 201yase (P450c17), P450 aromatase (P450arom) and produce pregnenolone, progesterone, dehydroepiandrosterone, androstenedion, oestradion and oestrone. Oligodendrocytes are predominantly the producer of myeline protein. The oligodendrocytes were identified by immunohistochemistry using a monoclonal antibody against myeline 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), a myeline specific enzyme. In this study we have examined the distribution of 3beta-HSD and CNPase by immunohistochemistry using monoclonal antibody in canine cerebellar cortex. The localization of oligodendrocytes within the cerebellar cortex was determined to be close to Purkinje neurones. This result suggests that endogenous progesterone synthesized de novo in the Purkinje neurone can promote myeline protein synthesis in oligodentrocytes.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/j.1439-0264.2004.00525.x
dc.identifier.endpage154en_US
dc.identifier.issn0340-2096
dc.identifier.issue3en_US
dc.identifier.pmid15144282
dc.identifier.scopus2-s2.0-2942628315
dc.identifier.scopusqualityQ2
dc.identifier.startpage151en_US
dc.identifier.urihttps://doi.org/10.1111/j.1439-0264.2004.00525.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3281
dc.identifier.volume33en_US
dc.identifier.wosWOS:000221913400006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Verlag Gmbhen_US
dc.relation.ispartofAnatomia Histologia Embryologia-Journal Of Veterinary Medicine Series C
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleNeurosteroidogenesis in oligodendrocytes and Purkinje neurones of cerebellar cortex of dogsen_US
dc.typeArticle

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