What is the protective effect of metformin on rat ovary against ischemia-reperfusion injury?

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dc.contributor.authorSayan, Cemile Dayangan
dc.contributor.authorKaraca, Gokhan
dc.contributor.authorOzkan, Zehra Sema
dc.contributor.authorTulmac, Ozlem B.
dc.contributor.authorIsik, Asli Ceylan
dc.contributor.authorDevrim, Tuba
dc.contributor.authorYeral, Ilkin
dc.date.accessioned2020-06-25T18:29:45Z
dc.date.available2020-06-25T18:29:45Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionOzkan, Zehra Sema/0000-0001-9185-3663
dc.description.abstractAimThe aim of this study was to investigate the protective effect of metformin on the rat ovary against ischemia-reperfusion injury. MethodsThirty-seven female Wistar albino rats were used in the study. The rats were divided into five groups, as follows: sham operation group (group 1); torsion group (group 2); torsion/detorsion+saline group (group 3); torsion/detorsion+low-dose metformin group (group 4); and torsion/detorsion+high-dose metformin group (group 5). The right ovary from each rat was evaluated histologically using hematoxylin-eosin staining, and the left ovaries were evaluated for tissue levels of the reduced-glutathione-to-oxidized-glutathione ratio, malondialdehyde (MDA), and caspase-3 activation. ResultsThe highest damage score was observed in group 3, and the lowest score was observed in group 1. The tissue caspase-3 activity levels of groups 2, 3, and 4 were significantly higher than those of group 1. The difference between group 1 and group 5 in terms of tissue caspase-3 activity was not significant (P=0.4). The reduced-glutathione-to-oxidized-glutathione ratio of group 1 was significantly higher than the ratios found in groups 2, 3, and 4. The tissue MDA level of group 1 was significantly lower than the levels found in groups 2, 3, 4, and 5. The tissue MDA level of group 5 was significantly lower than the levels in groups 3 and 4. ConclusionFrom both histopathological and biochemical analyses, the results of the study demonstrated that metformin has beneficial effects when it comes to attenuating ovarian ischemia-reperfusion injury.en_US
dc.description.sponsorshipKirikkale University Scientific Research Commission [2015/72]en_US
dc.description.sponsorshipThis research was funded by Kirikkale University Scientific Research Commission (project number: 2015/72). The authors are grateful to the staff members of Kirikkale University for their valuable support.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/jog.13524
dc.identifier.endpage285en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue2en_US
dc.identifier.pmid29144016
dc.identifier.scopus2-s2.0-85034088826
dc.identifier.scopusqualityQ2
dc.identifier.startpage278en_US
dc.identifier.urihttps://doi.org/10.1111/jog.13524
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7447
dc.identifier.volume44en_US
dc.identifier.wosWOS:000424844400013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Obstetrics And Gynaecology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectischemia-reperfusion injuryen_US
dc.subjectmetforminen_US
dc.subjectovaryen_US
dc.subjectraten_US
dc.subjectreactive oxygen speciesen_US
dc.titleWhat is the protective effect of metformin on rat ovary against ischemia-reperfusion injury?en_US
dc.typeArticle

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