Expression of angiogenic growth factors in canine squamous cell cancers
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Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TAYLOR & FRANCIS LTD
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Skin and subcutaneous tissue tumors are the most common neoplasms in dogs. The most common sites of origin in dogs include digits, skin and the oral cavity including cheek and retromandibular area. We investigated canine squamous cell carcinoma (SCC) samples from 15 dogs and classified them histopathologically according to the degree of differentiation. bFGF, VEGF-C, TGF-beta, PDGF-A, PDGF-C and PDGFR-alpha expressions were assessed using immunohistochemistry to determine the roles of growth factors during SCC. We found that TGF-beta 1 immunolabeling was elevated significantly compared to healthy controls in SCC originating from nailbeds, while expression of other growth factors did not change significantly. Our findings might explain the role of TGF-beta 1 in the infiltrative and malignant behavior of SCC originating from nailbeds.
Açıklama
Anahtar Kelimeler
Angiogenesis, bFGF, canine, growth factors, PDGF, squamous cell carcinoma, TGF beta 1, VEGF-C
Kaynak
BIOTECHNIC & HISTOCHEMISTRY
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
Sayı
Künye
closedAccess
