Expression of angiogenic growth factors in canine squamous cell cancers

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dc.contributor.authorSozmen, M.
dc.contributor.authorDevrim, A. K.
dc.contributor.authorSudagidan, M.
dc.contributor.authorKabak, Y. B.
dc.contributor.authorYildirim, F.
dc.date.accessioned2021-01-14T18:10:22Z
dc.date.available2021-01-14T18:10:22Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractSkin and subcutaneous tissue tumors are the most common neoplasms in dogs. The most common sites of origin in dogs include digits, skin and the oral cavity including cheek and retromandibular area. We investigated canine squamous cell carcinoma (SCC) samples from 15 dogs and classified them histopathologically according to the degree of differentiation. bFGF, VEGF-C, TGF-beta, PDGF-A, PDGF-C and PDGFR-alpha expressions were assessed using immunohistochemistry to determine the roles of growth factors during SCC. We found that TGF-beta 1 immunolabeling was elevated significantly compared to healthy controls in SCC originating from nailbeds, while expression of other growth factors did not change significantly. Our findings might explain the role of TGF-beta 1 in the infiltrative and malignant behavior of SCC originating from nailbeds.en_US
dc.description.sponsorshipScientific Projects Commission of Mehmet Akif Ersoy University, Burdur, Turkey [0170-NAP-13]en_US
dc.description.sponsorshipThis study was supported financially by Scientific Projects Commission of Mehmet Akif Ersoy University [Project number: 0170-NAP-13], Burdur, Turkey.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/10520295.2020.1818826
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.pmid33006294
dc.identifier.scopus2-s2.0-85092173756
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1080/10520295.2020.1818826
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12552
dc.identifier.wosWOS:000574958500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofBIOTECHNIC & HISTOCHEMISTRY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiogenesisen_US
dc.subjectbFGFen_US
dc.subjectcanineen_US
dc.subjectgrowth factorsen_US
dc.subjectPDGFen_US
dc.subjectsquamous cell carcinomaen_US
dc.subjectTGF beta 1en_US
dc.subjectVEGF-Cen_US
dc.titleExpression of angiogenic growth factors in canine squamous cell cancersen_US
dc.typeArticle

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