Urinary neopterin levels in the different stages of pregnancy

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dc.contributor.authorBoyunağa, Hakan
dc.contributor.authorBayram, Merih
dc.contributor.authorKeles, Hatice
dc.contributor.authorYücel, Aykan
dc.contributor.authorSağsöz, Nevin
dc.contributor.authorÖzer, Güler
dc.contributor.authorAkgül, Emin Özgür
dc.date.accessioned2020-06-25T17:40:51Z
dc.date.available2020-06-25T17:40:51Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.descriptionYucel, Aykan/0000-0002-5888-692X
dc.description.abstractBackground/Aims: Neopterin is a biochemical marker of activated cell-mediated immune response which increases in pathological conditions associated with cellular immune activation as well as in pregnancy where cellular immune response is predominant. The aim of this study was to determine the urinary neopterin level in each trimester of pregnancy and to determine if it can be used as a marker. Methods: 104 healthy pregnant women ( mean age 22.10 +/- 4.39 years; 36 in the first, 30 in the second and 38 in the third trimester) and 16 nonpregnant healthy women ( mean age 20.94 +/- 4.48 year) were included. Results: The mean urinary neopterin concentration of all pregnant women was higher than that of non-pregnant women (166.4 +/- 31.7 and 103.1 +/- 27.5 mu mol/mol creatinine respectively, p < 0.01). The mean urinary neopterin levels in each trimester and nonpregnant women were 139.8 +/- 49.6, 131 +/- 40.2, 227.9 +/- 86.5 and 103.1 +/- 27.5 mu mol/mol creatinine, respectively. Urinary neopterin levels were not significantly different between non-pregnant, first and second trimester groups, but were significantly higher in the third trimester than each of these groups ( p < 0.05, p < 0.01 and p < 0.01 respectively). Conclusion: Urinary neopterin levels increase significantly in the third trimester probably due to more predominated cellular immunity. The pathologies causing cellular immune activation, especially in the first two trimesters can be predicted with urinary neopterin levels. Copyright (C) 2005 S. Karger AG, Basel.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1159/000083748
dc.identifier.endpage174en_US
dc.identifier.issn0378-7346
dc.identifier.issue3en_US
dc.identifier.pmid15692214
dc.identifier.scopus2-s2.0-17844401238
dc.identifier.scopusqualityQ2
dc.identifier.startpage171en_US
dc.identifier.urihttps://doi.org/10.1159/000083748
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3568
dc.identifier.volume59en_US
dc.identifier.wosWOS:000228257200011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKargeren_US
dc.relation.ispartofGynecologic And Obstetric Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectneopterinen_US
dc.subjectpregnancyen_US
dc.subjectinflammationen_US
dc.subjectcellular immunityen_US
dc.titleUrinary neopterin levels in the different stages of pregnancyen_US
dc.typeArticle

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