Differential Expression of EGFR-1, MMP-3, and MMP-9 in Spontaneous Abortions, Induced Abortions, and Tubal Pregnancies

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dc.contributor.authorBalci, Mahi
dc.contributor.authorOzdemir, Gulhan
dc.date.accessioned2020-06-25T18:34:37Z
dc.date.available2020-06-25T18:34:37Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: The purpose of our study was to assess trophoblastic and uterine sufficiency in miscarriage pathogenesis with immunohistochemical methods and to determine if they could be used as a screening tool for the risk of miscarriage in the future. Material and Method: Placental tissue specimens that were comprised of 20 spontaneous abortions, 23 voluntarily terminated (induced) abortions, and 12 tubal pregnancies were included in this study. Trophoblastic cells and implantation area were evaluated for staining with EGFR-1, MMP-3, and MMP-9 by immunohistochemistry. Results: EGFR-1 expression was more intense and diffuse in decidual cells in the placental bed of spontaneous abortion specimens; this difference was statistically significant (P=0.004). MMP-3 expression was markedly increased in villous and extravillous trophoblastic cells in induced abortions; the difference between the groups was found to be statistically significant (P values ranged from < 0.01 to 0.005). MMP-9 expression tended to be higher in spontaneous abortion and tubal pregnancy specimens, and the results were statistically significant as P values were lower than 0.01. Conclusion: Higher EGFR-1 expression in the decidual tissue of spontaneous abortion specimens suggests that EGFR-1 triggers the migration of extravillous trophoblasts, leading to their destructive invasion. Similarly, MMP-9 immunopositivity might be indicative of aggressive invasion contributing to spontaneous abortion pathogenesis. Relatively high levels of MMP-3 expression in induced abortion specimens used as a control group might be a predictor of successful implantation, whereas its decreased expression might be indicative of risk for pregnancy loss.en_US
dc.description.sponsorshipKirikkale University Research Project UnitKirikkale University [2012-80]en_US
dc.description.sponsorshipOur study was financially supported by Kirikkale University Research Project Unit. The Project number: 2012-80.en_US
dc.identifier.citationBalcı M., Özdemir G. (2019). Differential Expression of EGFR-1, MMP-3, and MMP-9 in Spontaneous Abortions, Induced Abortions, and Tubal Pregnancies. Türk Patoloji Dergisi, 35(1), 1 - 8.en_US
dc.identifier.doi10.5146/tjpath.2018.01432
dc.identifier.endpage8en_US
dc.identifier.issn1018-5615
dc.identifier.issn1309-5730
dc.identifier.issue1en_US
dc.identifier.pmid30596394
dc.identifier.scopus2-s2.0-85059496290
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.trdizinid296180
dc.identifier.urihttps://doi.org/10.5146/tjpath.2018.01432
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7978
dc.identifier.volume35en_US
dc.identifier.wosWOS:000459768100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherDe Gruyter Poland Sp Zooen_US
dc.relation.ispartofTurkish Journal Of Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSpontaneous abortionen_US
dc.subjectInduced abortionen_US
dc.subjectEpidermal growth factor receptoren_US
dc.subjectMetalloproteinasesen_US
dc.subjectTubal pregnancyen_US
dc.titleDifferential Expression of EGFR-1, MMP-3, and MMP-9 in Spontaneous Abortions, Induced Abortions, and Tubal Pregnanciesen_US
dc.typeArticle

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