Immunolocalization of 3β-hydroxysteroid dehydrogenase in normal and hyperplastic ram prostates

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dc.contributor.authorYarım, Murat
dc.contributor.authorKarahan, Siyami
dc.contributor.authorKabakcı, Nalan
dc.contributor.authorAtmaca, Tarık
dc.date.accessioned2020-06-25T17:41:11Z
dc.date.available2020-06-25T17:41:11Z
dc.date.issued2006
dc.departmentKırıkkale Üniversitesi
dc.description/0000-0002-0636-4214; ATMACA, HASAN TARIK/0000-0001-8379-4114
dc.description.abstractThe enzyme 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) is essential in the synthesis of all steroids by cleaving dehydroepiandrosterone to androstenedione. In the present study, 3 beta-HSD immunoreactivity was investigated in the prostate of Akkaraman breed rams aged older than 3 years. Five normal and five hyperplastic ram prostates were processed for immunohistochernistry. Prostate hyperplasia was determined by histopathological evaluation of 375 ram prostate and confirmed with significantly (P < 0.01) increased number of cells expressing proliferating cell nuclear antigen (PCNA) immunoreactivity in the glandular epithelia. The 3 beta-HSD immunoreactivity with a variable intensity and pattern of distribution was present in the glandular epithelia and endothelia of blood vessels in normal and hyperplastic ram prostates. While immunoreactivity was focally present in some glands, some sections had a homogenous distribution. The presence of 3 beta-HSD immunoreactivity indicates that steroids are locally synthesized in the ram prostate. No differences in the distribution pattern of 3 beta-HSD immunoreactivity and the percentage of immunoreactive cells were observed between normal and hyperplastic prostates (P > 0.05), suggesting that locally produced steroids have little or no effect onthe pathogenesis of the ram prostate hyperplasia which affects a very small proportion of the ram population (5 out of 375). (c) 2005 Elsevier Inc. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.domaniend.2005.05.003
dc.identifier.endpage27en_US
dc.identifier.issn0739-7240
dc.identifier.issue1en_US
dc.identifier.pmid16009527
dc.identifier.scopus2-s2.0-27844436095
dc.identifier.scopusqualityQ1
dc.identifier.startpage17en_US
dc.identifier.urihttps://doi.org/10.1016/j.domaniend.2005.05.003
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3648
dc.identifier.volume30en_US
dc.identifier.wosWOS:000233827400002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofDomestic Animal Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject3 beta-hydroxysteroid dehydrogenaseen_US
dc.subjecthyperplasiaen_US
dc.subjectimmunohistochemistryen_US
dc.subjectramen_US
dc.subjectprostateen_US
dc.titleImmunolocalization of 3β-hydroxysteroid dehydrogenase in normal and hyperplastic ram prostatesen_US
dc.typeArticle

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