Cranial bone regeneration via BMP-2 encoding mesenchymal stem cells

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dc.contributor.authorVural, Altugan Cahit
dc.contributor.authorOdabas, Sedat
dc.contributor.authorKorkusuz, Petek
dc.contributor.authorSaglam, Atiye Seda Yar
dc.contributor.authorBilgic, Elif
dc.contributor.authorCavusoglu, Tarik
dc.contributor.authorVargel, Ibrahim
dc.date.accessioned2020-06-25T18:23:14Z
dc.date.available2020-06-25T18:23:14Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionOdabas, Sedat/0000-0002-7844-7019; KORKUSUZ, PETEK/0000-0002-7553-3915
dc.description.abstractCranial bone repair and regeneration via tissue engineering principles has attracted a great deal of interest from researchers during last decade. Here, within this study, 6mm critical-sized bone defect regeneration via genetically modified mesenchymal stem cells (MSC) were monitored up to 4 months. Cranial bone repair and new bone formations were evaluated by histological staining and real time PCR analysis in five different groups including autograft and bone morphogenetic protein-2 (BMP-2) transfected MSC groups. Results presented here indicate a proper cranial regeneration in autograft groups and a prospering regeneration for hBMP-2 encoding mesenchymal stem cells.en_US
dc.description.sponsorshipTurkish Academy of Sciences (TUBA)Turkish Academy of Sciences; Kirikkale University Scientific Research Projects Coordination UnitKirikkale Universityen_US
dc.description.sponsorshipErhan Piskin was supported by the Turkish Academy of Sciences (TUBA) as a full member. This study is partially supported by Kirikkale University Scientific Research Projects Coordination Unit.en_US
dc.identifier.citationAltugan Cahit Vural, Sedat Odabas, Petek Korkusuz, Atiye Seda Yar Sağlam, Elif Bilgiç, Tarık Çavuşoğlu, Erhan Piskin & İbrahim Vargel (2017) Cranial bone regeneration via BMP-2 encoding mesenchymal stem cells, Artificial Cells, Nanomedicine, and Biotechnology, 45:3, 544-550.en_US
dc.identifier.doi10.3109/21691401.2016.1160918
dc.identifier.endpage550en_US
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue3en_US
dc.identifier.pmid27002739
dc.identifier.scopus2-s2.0-84961390026
dc.identifier.scopusqualityQ1
dc.identifier.startpage544en_US
dc.identifier.urihttps://doi.org/10.3109/21691401.2016.1160918
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7050
dc.identifier.volume45en_US
dc.identifier.wosWOS:000394598300019
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArtificial Cells Nanomedicine And Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone morphogenetic protein-2en_US
dc.subjectcranial bone regenerationen_US
dc.subjectcritical size defecten_US
dc.subjectmesenchymal stem cellen_US
dc.subjecttransfectionen_US
dc.titleCranial bone regeneration via BMP-2 encoding mesenchymal stem cellsen_US
dc.typeArticle

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