Epithelial expression of extracellular matrix metalloproteinase inducer/CD147 and matrix metalloproteinase-2 in neoplasms and precursor lesions derived from cutaneous squamous cells: An immunohistochemical study

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dc.contributor.authorAyva, Sebnem Kupana
dc.contributor.authorKarabulut, Ayse Anil
dc.contributor.authorAkatli, Ayse Nur
dc.contributor.authorAtasoy, Pinar
dc.contributor.authorBozdogan, Onder
dc.date.accessioned2020-06-25T18:07:35Z
dc.date.available2020-06-25T18:07:35Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractExtracellular matrix metalloproteinase inducer (CD147) is a transmembrane glycoprotein involved in the regulation of matrix metalloproteinases (MMPs). The study investigated CD147 and MMP-2 expression in epidermis of cutaneous squamous lesions. CD147 and MMP-2 expressions were evaluated immunohistochemically in 44 specimens: 18 actinic keratoses (AK), 6 squamous cell carcinomas in situ (SCCIS), 13 squamous cell carcinomas (SCC; peritumoral and invasive portions assessed), and 7 normal skins. Patterns of expression were assessed, with MMP-2 in nuclei (MMP-2n) and cytoplasm (MMP-2c) evaluated separately. The expression of each marker was quantified using a calculated immunohistochemical/histologic score (H-score). Correlations were analyzed for the marker H-scores in each study group. Associations between H-scores and histopathologic parameters were also evaluated. CD147 H-score was the highest in SCC (invasive islands), followed by AK, SCCIS, and control specimens, respectively. MMP-2n and MMP-2c H-scores were the highest in AK, followed by SCCIS, SCC, and control specimens, respectively. MMP-2c and MMP-2n H-scores were significantly higher in peritumoral epidermis than in invasive islands of SCC. MMP-2c and CD147 H-scores were positively correlated in the peritumoral SCCs. CD147 H-score was positively correlated with tumor differentiation in SCC. The findings suggest that overexpression of CD147 plays a role in the development of SCC. (C) 2013 Elsevier GmbH. All rights reserved.en_US
dc.description.sponsorshipKirikkale University Scientific Research CommitteeKirikkale Universityen_US
dc.description.sponsorshipThe project was supported by Kirikkale University Scientific Research Committee.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.prp.2013.07.002
dc.identifier.endpage634en_US
dc.identifier.issn0344-0338
dc.identifier.issue10en_US
dc.identifier.pmid23948694
dc.identifier.scopus2-s2.0-84885843378
dc.identifier.scopusqualityQ2
dc.identifier.startpage627en_US
dc.identifier.urihttps://doi.org/10.1016/j.prp.2013.07.002
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5616
dc.identifier.volume209en_US
dc.identifier.wosWOS:000326996100003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Gmbh, Urban & Fischer Verlagen_US
dc.relation.ispartofPathology Research And Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCD147en_US
dc.subjectBasiginen_US
dc.subjectMetalloproteinasesen_US
dc.subjectActinic keratosisen_US
dc.subjectCutaneous squamous cell carcinomaen_US
dc.titleEpithelial expression of extracellular matrix metalloproteinase inducer/CD147 and matrix metalloproteinase-2 in neoplasms and precursor lesions derived from cutaneous squamous cells: An immunohistochemical studyen_US
dc.typeArticle

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