Lower plasma pantoprazole level predicts Helicobacter pylori treatment failure in patients with type 2 diabetes mellitus

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dc.contributor.authorSapmaz, Ferdane
dc.contributor.authorKalkan, Ismail H.
dc.contributor.authorSuslu, Incilay
dc.contributor.authorDemirci, Huseyin
dc.contributor.authorAtasoy, Pinar
dc.contributor.authorGuliter, Sefa
dc.date.accessioned2020-06-25T18:12:55Z
dc.date.available2020-06-25T18:12:55Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectiveWe aimed to compare the plasma pantoprazole level (PPL) between patients with type 2 diabetes mellitus and non-diabetic patients during Helicobacter pylori (H. pylori) eradication treatment and to explore the role of PPL in predicting the treatment success rates. MethodsThis study included 40 diabetic and 40 non-diabetic treatment-naive H.pylori-infected patients. Bismuth-based standard quadruple treatment for H.pylori eradication was used for 14 days in both groups. PPL was measured using the square-wave voltammetry method. ResultsH.pylori eradication rate (60.0% vs 87.5%, P=0.005) and PPL (0.25 0.03 g/mL vs 0.34 +/- 0.03 g/mL, P < 0.001) was significantly lower in the diabetic group compared with the controls. Patients with treatment failure had lower PPL than those with successful treatment (P<0.001). The receiver operating characteristics curve demonstrated that PPL had a significant predictive value for the outcome of H.pylori eradication. ConclusionType 2 diabetic patients had lower PPL than the non-diabetic controls, which led to their lower H. pylori eradication rates.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/1751-2980.12272
dc.identifier.endpage536en_US
dc.identifier.issn1751-2972
dc.identifier.issn1751-2980
dc.identifier.issue9en_US
dc.identifier.pmid26147605
dc.identifier.scopus2-s2.0-84942514209
dc.identifier.scopusqualityQ2
dc.identifier.startpage531en_US
dc.identifier.urihttps://doi.org/10.1111/1751-2980.12272
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6078
dc.identifier.volume16en_US
dc.identifier.wosWOS:000362088800007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Digestive Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecteradicationen_US
dc.subjectplasma pantoprazole levelen_US
dc.subjecttype 2 diabetes mellitusen_US
dc.titleLower plasma pantoprazole level predicts Helicobacter pylori treatment failure in patients with type 2 diabetes mellitusen_US
dc.typeArticle

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