Effects of hyperbaric oxygen treatment on liver functions, oxidative status and histology in septic rats

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dc.contributor.authorOter, Şükrü
dc.contributor.authorEdremitlioğlu, Mustafa
dc.contributor.authorKorkmaz, Ahmet
dc.contributor.authorCoşkun, Ömer
dc.contributor.authorKılıç, Dilek
dc.contributor.authorKısa, Üçler
dc.contributor.authorBilgiç, Hayati
dc.date.accessioned2020-06-25T17:40:26Z
dc.date.available2020-06-25T17:40:26Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810; Oter, Sukru/0000-0002-3361-1313
dc.description.abstractObjective: The liver is thought to be responsible for multiple organ failure during sepsis. Increase in tissue oxygen consumption is a major component of the septic response. Hyperbaric oxygen (HBO) therapy provides more oxygenation in the whole body. This study examined the effect of HBO alone or in combination with cefepime (CEF) on the liver in septic rats. Design and interventions: We divided 90 male rats into six groups; control, HBO, sepsis (SEP), SEP+HBO, SEP+CEF, and SEP+CEF+HBO. Sepsis was induced with an intraperitoneal injection of Escherichia coli (2.1x10(9) cfu). A total of six HBO sessions were performed at 2 atm absolute for 90 min at 6-h intervals. CEF was administered intraperitoneally at a dose of 50 mg/kg twice daily. Animals were killed 48 h after sepsis induction. Their liver and blood were removed for biochemical and histopathological analysis. Measurements and results: Liver thiobarbituric acid reactive substances as well as serum alanine transaminase, aspartate transaminase and alkaline phosphatase levels increased while the activity of the antioxidant enzymes superoxide dismutase and catalase decreased significantly in septic rats. These parameters returned to nearly control levels in the SEP+CEF+HBO group. Histological observations supported these findings: Hepatocellular degeneration was observed and intensive polymorphonuclear cell infiltration appeared in all fields of septic animal livers. HBO alone could not sufficiently reverse these histopathological changes, but most liver sections presented normal histology when it was combined with CEF. Conclusions: HBO may be a useful adjuvant therapy modality to improve the efficacy of sepsis treatment.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00134-005-2701-6
dc.identifier.endpage1268en_US
dc.identifier.issn0342-4642
dc.identifier.issn1432-1238
dc.identifier.issue9en_US
dc.identifier.pmid16034622
dc.identifier.scopus2-s2.0-25144484862
dc.identifier.scopusqualityQ1
dc.identifier.startpage1262en_US
dc.identifier.urihttps://doi.org/10.1007/s00134-005-2701-6
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3437
dc.identifier.volume31en_US
dc.identifier.wosWOS:000231949200020
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofIntensive Care Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEscherichia colien_US
dc.subjectsepsisen_US
dc.subjecthyperbaric oxygenen_US
dc.subjectliveren_US
dc.subjectoxidative stressen_US
dc.subjectantioxidant enzymesen_US
dc.titleEffects of hyperbaric oxygen treatment on liver functions, oxidative status and histology in septic ratsen_US
dc.typeArticle

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