Neopterin levels in nonreplicative HBV carriers

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dc.contributor.authorKilic, D.
dc.contributor.authorBoyunaga, H.
dc.contributor.authorKaygusuz, S.
dc.contributor.authorAkgul, E.O.
dc.contributor.authorAl Rashed, M.
dc.contributor.authorKenar, L.
dc.contributor.authorKutluay, T.
dc.date.accessioned2020-06-25T17:34:59Z
dc.date.available2020-06-25T17:34:59Z
dc.date.issued2002
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe aim of this study was to determine the existence of immune activation by measuring neopterin in HBV (Hepatitis B virus) carriers with viral load (HBV DNA) less than 5 pg/ml. Forty-three subjects and 56 healthy controls were included in the study. Neopterin levels of were compared. ALT and ALP levels in one patient and AST levels in two patients were found minimally higher than upper limit, and GGT levels were within the reference range in all patients. Neopterin levels in the patient group and in the controls were 159.97 +/- 13.39 and 84.10 +/- 11.45 nmol/l, respectively (P < 0.0001). The difference between the two groups was statistically significant (P < 0.0001). In conclusion, the increased neopterin levels of HBV carriers might be the indicators of the effect of cellular immunity. This increase might also implicate a background inflammation based on mainly cellular immunity that exists within the liver. (C) 2002 Elsevier Science B.V. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/S1386-6346(02)00012-8
dc.identifier.endpage22en_US
dc.identifier.issn1386-6346
dc.identifier.issue1en_US
dc.identifier.pmid12243788
dc.identifier.scopus2-s2.0-0036740515
dc.identifier.scopusqualityQ1
dc.identifier.startpage18en_US
dc.identifier.urihttps://doi.org/10.1016/S1386-6346(02)00012-8
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2979
dc.identifier.volume24en_US
dc.identifier.wosWOS:000178412300003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ireland Ltden_US
dc.relation.ispartofHepatology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectneopterinen_US
dc.subjectHBV carriageen_US
dc.subjecthepatitis B virusen_US
dc.titleNeopterin levels in nonreplicative HBV carriersen_US
dc.typeArticle

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