Plasma leptin concentrations in postmenopausal women with osteoporosis

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dc.contributor.authorYılmazı, Murat
dc.contributor.authorKeleş, Işık
dc.contributor.authorAydın, Gülümser
dc.contributor.authorOrkun, Sevim
dc.contributor.authorBayram, Merih
dc.contributor.authorSevinç, F. Ceylan
dc.contributor.authorYetkin, İlhan
dc.contributor.authorÜçler, Kısa
dc.date.accessioned2020-06-25T17:40:50Z
dc.date.available2020-06-25T17:40:50Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810
dc.description.abstractOsteoporosis is less common in obese individuals with increased bone mineral density (BMD) and plasma leptin concentrations. The aim of this study was to determine the correlation between leptin levels and BMD in postmenopausal women. The study consisted of 90 postmenopausal women with a mean age of 53.45 +/- 0.87 years who visited our outpatient clinic for the evaluation of BMD. Thirty-six postmenopausal women with osteoporosis (mean age: 54.52 +/- 1.41 years and mean body mass index (BMI, kg/m 2 ) 29.33 +/- 0.66), 30 age- and BMI-matched postmenopausal women with normal BMD, and 24 postmenopausal women (mean age: 52.79 +/- 1.48 years and mean BMI: 29.45 +/- 0.89) with osteopenic BMD were included in the study. Plasma concentrations of leptin after an overnight fast were measured by radioimmunoassay. BMD values were measured by dual-energy X-ray absorptiometry (DEXA) at the L 2 -L 4 lumbar spine and femoral neck. The median spine BMD value in the patient group (0.67 +/- 0.08 g/cm(2) , mean +/- SEM) was significantly lower than that in the control group (1.02 +/- 0.25 g/cm 2 , mean + SEM) and osteopenic group (0.87 +/- 0.05 g/cm 2 , mean + SEM) (p < 0.150). Plasma leptin concentrations were correlated with BMI in three groups (r(s) = 0.450, p = 0.025 in normal BMD group and r(s) = 0.4254, P = 0.009 in the osteoporotic group, and r(s) = 395, p = 0.015 in the osteopenia group. There was no correlation between plasma leptin concentrations and BMD values in three groups (r(s) = -0.89 in normal BMD group, r(s) = -0.124 in osteopenia group, and r(s) = -0.195 in osteoporosis group). From this study we conclude that circulating plasma leptin does not have a significant direct influence on bone mass in postmenopausal women.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1080/07435800500229276
dc.identifier.endpage138en_US
dc.identifier.issn0743-5800
dc.identifier.issn1532-4206
dc.identifier.issue2en_US
dc.identifier.pmid16353671
dc.identifier.scopus2-s2.0-28844471473
dc.identifier.scopusqualityQ3
dc.identifier.startpage133en_US
dc.identifier.urihttps://doi.org/10.1080/07435800500229276
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3563
dc.identifier.volume31en_US
dc.identifier.wosWOS:000233635000006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofEndocrine Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectleptinen_US
dc.subjectosteoporosisen_US
dc.subjectpostmenopausal womenen_US
dc.titlePlasma leptin concentrations in postmenopausal women with osteoporosisen_US
dc.typeArticle

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