The effects of magnesium sulphate on the contractile activity of uterus in an animal model of preeclampsia

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dc.contributor.authorYildirim, E.
dc.contributor.authorMacun, H. C.
dc.contributor.authorCinar, M.
dc.contributor.authorYigit, A. A.
dc.contributor.authorUstuner, I.
dc.contributor.authorAydos, T. R.
dc.contributor.authorAktuna, Z.
dc.date.accessioned2020-06-25T18:12:24Z
dc.date.available2020-06-25T18:12:24Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionAydos, Tolga Resat/0000-0002-1832-9336;
dc.description.abstractPurpose: This study was undertaken to evaluate the effects of magnesium sulfate (MgSO4) on the contractile activity of the uterus in a pregnant rat model of preeclampsia induced by N-nitro-arginine methyl ester (L-NAME). Materials and Methods: Twenty-eight, 160220 gram, three to four month old female Sprague-Dawley rats were used in this study. After conception was confirmed by vaginal smears on the first day of pregnancy, the animals were allocated into four groups according to the chemicals fed in their drinking water as control (nothing administered), L-NAME (50 mg/kg L-NAME), MgSO4 (600 mg/kg MgSO4), and MgSO4 + L-NAME group (600 mg/kg MgSO4 + 50 mg/kg L-NAME). The pregnant uterus strips were isolated on the 19th day and the contractile activity of uterus was examined by applying 0, 0.1, 0.2, 0.4, 0.8, and 2.5 mIU/mloxytocin to each group and responses are recorded accordingly. Results: There were no statistically significant differences regarding fetal parameters and peak amplitudes of the oxytocin stimulated pregnant rat myometrial strips among groups. In L-NAME group at 0 and 0.1 mIU/ml oxytocin, the contraction frequency in a ten-min period was statistically lower than the control group (Z = -2.850, p = 0.004; Z = -2.902, p = 0.004, respectively). In MgSO4 group only at 0 mIU/ml oxytocin, the frequencies of the contractions in ten-min period were statistically lower than the control group (Z = -2.973,p = 0.003). In L-NAME + MgSO4 group at 0, 0.1 and 0.2 mIU/ml oxytocin concentrations the frequencies of the contractions in ten-min period were statistically lower than the control group (Z = -4.018, p = 0.000; Z= -3.23'7,p = 0.001; Z= -2.902, p = 0.004, respectively). In L-NAME + MgSO4 given group at each oxytocin concentrations, the frequencies of the contractions in ten-min period were lower but not statistically different than the L-NAME group. Conclusion: MgSO4 has no significant effect on the amplitude of spontaneous or oxytocin induced myometrial contractions, but decreased the frequency of spontaneous contractions. At each doses of oxytocin, MgSO4 has no significant effect on the frequency of contraction in a pregnant rat model of preeclampsia induced by L-NAME.en_US
dc.description.sponsorshipKirikkale UniversityKirikkale University [2006/20]en_US
dc.description.sponsorshipThis study was supported by the Kirikkale University Research Fund Project No. 2006/20.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage173en_US
dc.identifier.issn0390-6663
dc.identifier.issue2en_US
dc.identifier.pmid24779245
dc.identifier.scopus2-s2.0-84898856971
dc.identifier.scopusqualityQ4
dc.identifier.startpage169en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5902
dc.identifier.volume41en_US
dc.identifier.wosWOS:000343848700015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisher7847050 Canada Incen_US
dc.relation.ispartofClinical And Experimental Obstetrics & Gynecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMagnesium sulfateen_US
dc.subjectL-NAMEen_US
dc.subjectUterusen_US
dc.subjectPreeclampsiaen_US
dc.titleThe effects of magnesium sulphate on the contractile activity of uterus in an animal model of preeclampsiaen_US
dc.typeArticle

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