Frequencies of serum antibodies to Helicobacter pylori CagA and VacA in a Turkish population with various gastroduodenal diseases

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dc.contributor.authorSezikli, M.
dc.contributor.authorGuliter, S.
dc.contributor.authorApan, T. Z.
dc.contributor.authorAksoy, A.
dc.contributor.authorKeleş, H.
dc.contributor.authorÖzkurt, Z. N.
dc.date.accessioned2020-06-25T17:41:25Z
dc.date.available2020-06-25T17:41:25Z
dc.date.issued2006
dc.description.abstractInfection with Helicobacter pylori (H. pylori) strains secreting cytotoxin-associated gene A (CagA) and vacuolating cytotoxin A (VacA) proteins is associated with more severe gastroduodenal pathologies. However, this association varies among geographical regions and ethnic groups. We investigated the frequencies of antibodies to CagA and VacA proteins in 131 H. pylori-infected dyspeptic patients [40 duodenal ulcer (DU), 19 gastric ulcer (GU), 28 gastric cancer (GC), and 44 non-ulcer dyspepsia (NUD)] across 30 H. pylori-infected and endoscopically normal asymptomatic subjects (AS). Anti-CagA and anti-VacA antibodies were detected by Western blotting. The positivity rates of anti-CagA and anti-VacA antibodies were higher in patients with DU (92.5 and 75%), GU (89.5 and 84.2%) and GC (96.4 and 85.7%) than patients with NUD (70.5 and 50%) and AS (50 and 23.3%) (p < 0.05). CagA(+)VacA(+) phenotype was more frequent in patients with DU, GU and GC than patients with NUD and AS (75, 84.2, 85.7 vs. 47.7 and 20%, respectively) (p < 0.01). Our results showed that there is a significantly positive association between the presence of anti-CagA and anti-VacA antibodies and DU, GU and GC in our region.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/j.1742-1241.2005.00778.x
dc.identifier.endpage1243en_US
dc.identifier.issn1368-5031
dc.identifier.issue10en_US
dc.identifier.pmid16669834
dc.identifier.scopus2-s2.0-33748559423
dc.identifier.scopusqualityQ1
dc.identifier.startpage1239en_US
dc.identifier.urihttps://doi.org10.1111/j.1742-1241.2005.00778.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3708
dc.identifier.volume60en_US
dc.identifier.wosWOS:000240404300019
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofInternational Journal Of Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHelicobacter pylorien_US
dc.subjectCagAen_US
dc.subjectVacAen_US
dc.subjectWestern blottingen_US
dc.titleFrequencies of serum antibodies to Helicobacter pylori CagA and VacA in a Turkish population with various gastroduodenal diseasesen_US
dc.typeArticle

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