The effects of raloxifene and tibolone on homocysteine and vascular histopathological changes
[ X ]
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer-Verlag Italia Srl
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of the present study was to examine the effects of raloxifene (RLX) and tibolone (TBN) on plasma homocysteine (Hey) levels and their relationship with atherosclerotic changes in the walls of the carotid artery in ovariectomised rats. Thirty surgically ovariectomised Wistar albino rats after a menopausal period of 6 cycles were randomly assigned to receive RLX 0.01 mg/kg/day (n=10), TBN 0.04 mg/kg/day (n=10) and the same dose of placebo (n=10) for 6 cycles. Serum levels of vitamin B12, folate and Hey were measured and carotid arteries were examined histopathologically following the termination of treatment. Hey levels were 3.27 +/- 0.97, 2.57 +/- 0.32 and 2.28 +/- 0.12 mu mol/l, Vitamin B12 levels were 901.90 +/- 239.76, 694.70 +/- 112.20 and 631 +/- 309.44 pg/ml and folate levels were 73.80 +/- 12.71, 72.51 +/- 7.05 and 84.79 +/- 20.82 ng/ml in receiving RLX, TBN and placebo respectively. Hey levels were increased by RLX vs. placebo (P=0.006) but not by TBN vs. placebo (P=0.070). Vitamin B 12 levels were found to be elevated by TBN vs. the control group (P=0.041) but not by RLX vs. placebo (P=0.059). Histopathological examination of carotid arteries from rats receiving both RLX and TBN revealed no difference vs. placebo. Data obtained from the study support the view that neither RLX nor TBN appears to have a primary protective effect on vascular disease by effecting the metabolism of Hey at menopause.
Açıklama
KISA, Ucler/0000-0002-8131-6810; OZKAN, YESIM/0000-0002-1669-4962
Anahtar Kelimeler
hormone replacement therapy, tamoxifene, raloxifene, homocysteine, vascular histopathology
Kaynak
Clinical And Experimental Medicine
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
7
Sayı
4
Künye
closedAccess
