Effect of slow-release 5-fluorouracil on capsule formation around silicone breast implants: An experimental study with mice

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dc.contributor.authorCanter, Halil İbrahim
dc.contributor.authorKonas, Ersoy
dc.contributor.authorBozdoğan, Önder
dc.contributor.authorVargel, İbrahim
dc.contributor.authorÖzbatir, Bilgen
dc.contributor.authorÖner, Filiz
dc.contributor.authorErk, Yücel
dc.date.accessioned2020-06-25T17:43:34Z
dc.date.available2020-06-25T17:43:34Z
dc.date.issued2007
dc.description.abstractBackground: Capsule formation around breast implants, development of tendon adhesions after tendon repair, intestinal brits after laparatomies, hypertrophic scars in skin incisions all are the results of excessive collagen synthesis to the extracellular matrix by fibroblasts. Any intervention that leads to cessation of collagen synthesis in these clinical situations may help to prevent these untoward results of wound healing. Although 5-fluorouracil (5-FU) is used mainly as a cytotoxic drug in chemotherapy protocols, it decreases cellular metabolism and blocks protein synthesis only at lower concentrations. Findings have shown that 5-FU downregulates fibroblast proliferation and differentiation in vitro. It has been used to treat fibroproliferative disorders of the eye and skin and is thought to inhibit thymidylate synthetase, blocking DNA replication. Methods: This study used five treatment groups: (1) gelatin only, (2) silicone only, (3) silicone + gelatin, (4) silicone + gelatin containing 1 mg of 5-FU, and (5) silicone + gelatin containing 5 mg of 5-FU. The release kinetics of 5-FU from gelatin have been investigated by means of ultraviolet spectrophotometric analysis. Specimens were obtained on postoperative day 30. Gross evaluation and histopathologic examination were conducted for capsule formation and the development of inflammation. Results: The silicone group had the most prominent capsule formation among all the groups. The gelatin group was second, and the silicone + gelatin group was third. As compared with the other groups, the 5-FU-containing groups had the least capsule formation. The 5-mg 5-FU-containing group had the most inflammation. The silicone + gelatin group was second in inflammation. Although the silicone, gelatin, and 1-mg 5-FU-containing groups had the same means, the results of the silicone group showed the most divergent data within the group. Conclusions: Because 5-FU loaded to a gelatin carrier for its slow release seems to prevent capsule formation around silicone blocks, it may be used to prevent capsule formation around silicone breast implants.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00266-006-0172-y
dc.identifier.endpage679en_US
dc.identifier.issn0364-216X
dc.identifier.issn1432-5241
dc.identifier.issue6en_US
dc.identifier.pmid17578639
dc.identifier.scopus2-s2.0-36349009268
dc.identifier.scopusqualityQ1
dc.identifier.startpage674en_US
dc.identifier.urihttps://doi.org10.1007/s00266-006-0172-y
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3803
dc.identifier.volume31en_US
dc.identifier.wosWOS:000251090700009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofAesthetic Plastic Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcapsule formationen_US
dc.subjectcollagen synthesisen_US
dc.subject5-fluorouracilen_US
dc.subjectsilicone breast implanten_US
dc.titleEffect of slow-release 5-fluorouracil on capsule formation around silicone breast implants: An experimental study with miceen_US
dc.typeArticle

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