Effects of losartan treatment on T-cell activities and plasma leptin concentrations in primary hypertension
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Date
2001
Journal Title
Journal ISSN
Volume Title
Publisher
Sage Publications Ltd
Access Rights
info:eu-repo/semantics/openAccess
Abstract
Recent evidence shows that leptin may contribute to elevated blood pressure (BP) and interact with die renin-angiotensin-aldosterone and cellular immune systems. Altered T-cell activities and changes in T-cell si ratios have also been reported in hypertension. However, little is known about the effects of AT(1)-receptor antagonism on T-cell activities and plasma leptin concentrations in primary hypertension. We have, therefore, investigated the relationship between leptin and T-cell activities and the effect of an AT(1)-receptor antagonist, losartan, in primary, hypertension. Twenty recently-diagnosed and untreated young adults (11 males and 9 females, age; 39.9 +/- 7.6 years, range 23-49 years, BMI; 27.6 +/- 3.7 kg/m(2)) and 20 normotensive healthy, age-, sex- and BMI-matched controls were studied. The [H-3]-thymidine uptakes of cultured lymphocytes were determined, both spontaneously and after stimulation,with phytohaemagglutinin. The tests were performed before mid after three months of treatment with losartan. The results indicate that the blastogenic responses of T-cells to phytohaemagglutinin are significantly higher in the patient group compared with controls (p=0.02). After normalisation of BP. T-cell responses were significantly reduced and were lower than in the controls (P=0.01). Pretreatment plasma leptin levels were significantly higher in hypertensives than in controls (P=0.01). However, losartan treatment had no significant effect on leptin concentrations; moreover, no correlation between leptin levels and T-cell activity was found. Our data show that plasma leptin levels and T-cell activity are markedly enhanced in untreated essential hypertension and that die alteration of T-cell activity is not related to plasma leptin levels. Antihypertensive treatment with losartan decreases T-cell activities but does not influence plasma leptin levels. We conclude that leptin levels are not affected by AT(1)-receptor blockade and are not related to T-cell activity.
Description
Sonmez, Alper/0000-0002-9309-7715; KISA, Ucler/0000-0002-8131-6810
Keywords
primary hypertension, T-cell, leptin, AT(1)-receptor antagonism, phytohaemagglutinin
Journal or Series
Journal Of The Renin-Angiotensin-Aldosterone System
WoS Q Value
N/A
Scopus Q Value
Q1
Volume
2
Issue
2
Citation
Sönmez A, Kisa U, Uckaya G, et al. Effects of losartan treatment on T-cell activities and plasma leptin concentrations in primary hypertension. Journal of the Renin-Angiotensin-Aldosterone System. 2001;2(2):112-116. doi:10.3317/jraas.2001.011
