Effects of losartan treatment on T-cell activities and plasma leptin concentrations in primary hypertension

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dc.contributor.authorSönmez, A.
dc.contributor.authorKısa, Ü.
dc.contributor.authorUckaya, G.
dc.contributor.authorEyileten, T.
dc.contributor.authorCömert, B.
dc.contributor.authorKoç, B.
dc.contributor.authorÖzata, M.
dc.date.accessioned2020-06-25T17:34:51Z
dc.date.available2020-06-25T17:34:51Z
dc.date.issued2001
dc.departmentKırıkkale Üniversitesi
dc.descriptionSonmez, Alper/0000-0002-9309-7715; KISA, Ucler/0000-0002-8131-6810
dc.description.abstractRecent evidence shows that leptin may contribute to elevated blood pressure (BP) and interact with die renin-angiotensin-aldosterone and cellular immune systems. Altered T-cell activities and changes in T-cell si ratios have also been reported in hypertension. However, little is known about the effects of AT(1)-receptor antagonism on T-cell activities and plasma leptin concentrations in primary hypertension. We have, therefore, investigated the relationship between leptin and T-cell activities and the effect of an AT(1)-receptor antagonist, losartan, in primary, hypertension. Twenty recently-diagnosed and untreated young adults (11 males and 9 females, age; 39.9 +/- 7.6 years, range 23-49 years, BMI; 27.6 +/- 3.7 kg/m(2)) and 20 normotensive healthy, age-, sex- and BMI-matched controls were studied. The [H-3]-thymidine uptakes of cultured lymphocytes were determined, both spontaneously and after stimulation,with phytohaemagglutinin. The tests were performed before mid after three months of treatment with losartan. The results indicate that the blastogenic responses of T-cells to phytohaemagglutinin are significantly higher in the patient group compared with controls (p=0.02). After normalisation of BP. T-cell responses were significantly reduced and were lower than in the controls (P=0.01). Pretreatment plasma leptin levels were significantly higher in hypertensives than in controls (P=0.01). However, losartan treatment had no significant effect on leptin concentrations; moreover, no correlation between leptin levels and T-cell activity was found. Our data show that plasma leptin levels and T-cell activity are markedly enhanced in untreated essential hypertension and that die alteration of T-cell activity is not related to plasma leptin levels. Antihypertensive treatment with losartan decreases T-cell activities but does not influence plasma leptin levels. We conclude that leptin levels are not affected by AT(1)-receptor blockade and are not related to T-cell activity.en_US
dc.identifier.citationSönmez A, Kisa U, Uckaya G, et al. Effects of losartan treatment on T-cell activities and plasma leptin concentrations in primary hypertension. Journal of the Renin-Angiotensin-Aldosterone System. 2001;2(2):112-116. doi:10.3317/jraas.2001.011en_US
dc.identifier.doi10.3317/jraas.2001.011
dc.identifier.endpage116en_US
dc.identifier.issn1470-3203
dc.identifier.issn1752-8976
dc.identifier.issue2en_US
dc.identifier.pmid11881109
dc.identifier.scopus2-s2.0-0035382651
dc.identifier.scopusqualityQ1
dc.identifier.startpage112en_US
dc.identifier.urihttps://doi.org/10.3317/jraas.2001.011
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2925
dc.identifier.volume2en_US
dc.identifier.wosWOS:000171769700006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal Of The Renin-Angiotensin-Aldosterone System
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectprimary hypertensionen_US
dc.subjectT-cellen_US
dc.subjectleptinen_US
dc.subjectAT(1)-receptor antagonismen_US
dc.subjectphytohaemagglutininen_US
dc.titleEffects of losartan treatment on T-cell activities and plasma leptin concentrations in primary hypertensionen_US
dc.typeArticle

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