Differentiation of benign and malignant superficial soft tissue lesions using real-time strain elastography

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dc.authoridAnnac, Gokce/0000-0002-7070-7330
dc.authoridSungu, Nuran/0000-0001-5187-2616
dc.authoridARSLAN, HALIL/0000-0002-6552-1275
dc.authoridAksam, Ersin/0000-0003-3123-0397
dc.contributor.authorAnnac, Gokce
dc.contributor.authorCanyigit, Murat
dc.contributor.authorTan, Sinan
dc.contributor.authorAksam, Ersin
dc.contributor.authorSungu, Nuran
dc.contributor.authorArslan, Halil
dc.date.accessioned2025-01-21T16:34:24Z
dc.date.available2025-01-21T16:34:24Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground/aim: To evaluate benign and malignant cutaneous-subcutaneous lesions using real-time strain elastography (RTSE) and to compare the findings with histopathologic results. Materials and methods: Over a period of 10 months, 72 patients (38 with benign and 34 with malignant cutaneous and subcutaneous lesions) were prospectively included in this study. Elasticity patterns and strain ratios were examined for each lesion. Lesions were evaluated in 4 groups as yellow-red (soft; pattern-1), green-yellow (moderate; pattern-2), blue-green (hard; pattern-3) and blue (hardest; pattern-4). The stiffness of the lesions was displayed with strain ratios by comparing of a nearby reference tissue. The recorded images were compared with histopathologic findings. Results: On sonoelastograms, considering patterns 1-2 as benign and patterns 3-4 as malignant, the sensitivity, specificity, and positive and negative predictive values for the differentiation of malignant from benign lesions were 100%, 68.5%, 74%, and 100%, respectively. Considering a cut-off value of the strain ratio as > 3.05, the sensitivity, specificity, and positive and negative predictive values were 91%, 89%, 88%, and 92%, respectively. The area under the curve (AUC: 0.972) showed the excellent ability of strain elastography to differentiate benign and malignant lesions. Conclusion: RTSE is an important imaging tool to differentiate benign and malignant superficial soft tissue lesions. Our results suggest that RTSE can be used to predict malignancy since malignant lesions are more confidentially diagnosed than benign superficial soft tissue lesions on elastograms.
dc.identifier.doi10.3906/sag-2101-166
dc.identifier.endpage2967
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6
dc.identifier.pmid34391320
dc.identifier.scopus2-s2.0-85122972787
dc.identifier.scopusqualityQ1
dc.identifier.startpage2959
dc.identifier.trdizinid477624
dc.identifier.urihttps://doi.org/10.3906/sag-2101-166
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay477624
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23962
dc.identifier.volume51
dc.identifier.wosWOS:000731456300019
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectBenign; malignant; cutaneous; subcutaneous; real-time strain elastography
dc.titleDifferentiation of benign and malignant superficial soft tissue lesions using real-time strain elastography
dc.typeArticle

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