Protective effects of trapidil in ischemia-reperfusion injury due to testicular torsion and detorsion: An experimental study

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dc.contributor.authorSomuncu, Salih
dc.contributor.authorÇakmak, Murat
dc.contributor.authorErdoğan, Sibel
dc.contributor.authorCağlayan, Osman
dc.contributor.authorAkman, Hülya
dc.contributor.authorKaya, Murat
dc.date.accessioned2020-06-25T17:43:33Z
dc.date.available2020-06-25T17:43:33Z
dc.date.issued2006
dc.description.abstractObjective: We aimed to detect the preventive effects of trapidil in ischemia reperfusion (IR) injury due to testicular torsion and detorsion. Methods: Forty prepubertal albino rats were used. In the IR group, torsion was created by rotating the left testis over 2 h, and detorsion was done by untwisting the testis. Bilateral orchiectomies were performed after 4 h. In study group, 2-h torsion was performed and trapidil was administered as a single dose I h before detorsion. Bilateral orchiectomies were performed after 4 h. In the sham group, a sham operation was done. In the sham plus trapidil group, a sham operation was done and trapidil was administered as a single dose. Testicular tissue malondialdehyde (MDA), nitric oxide (NO) and total sulfhydryl (T-SH) levels were determined for each group. The grades of interstitial injury were determined in histopathologic examination. Results: The NO and MDA levels in the IR group were significantly higher than the study, sham and sham plus trapidil groups in the left testis (P < 0.05 P < 0.001 and P < 0.001, respectively). A statistical difference was not found among Study, sham and sham plus trapidil groups in the left testis in NO and MDA levels (P > 0.05). The T-SH level in the study group was significantly higher than in the IR. sham and sham plus trapidil groups in left testis P < 0.05). In the IR group (left testis), grade I interstitial injury was 30% (3/10), grade 2 injury was 60% (6/10) and grade 3 injury was 10% (1/10). In the study group (left testis), grade I interstitial injury was 30% (3/10) and there was no injury in 70% (7/10). Conclusion: Trapidil decreased free oxygen radical formation in testicular torsion and detorsion, and attenuated histopathological damage in the ipsilateral twisted testis.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/j.1442-2042.2006.01355.x
dc.identifier.endpage605en_US
dc.identifier.issn0919-8172
dc.identifier.issue5en_US
dc.identifier.pmid16771732
dc.identifier.scopus2-s2.0-33646786444
dc.identifier.scopusqualityQ1
dc.identifier.startpage601en_US
dc.identifier.urihttps://doi.org10.1111/j.1442-2042.2006.01355.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3795
dc.identifier.volume13en_US
dc.identifier.wosWOS:000237600700020
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofInternational Journal Of Urology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfree oxygen radicalsen_US
dc.subjectischemia-reperfusion injuryen_US
dc.subjecttestis torsion-detorsionen_US
dc.subjecttrapidilen_US
dc.titleProtective effects of trapidil in ischemia-reperfusion injury due to testicular torsion and detorsion: An experimental studyen_US
dc.typeArticle

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