The impact of Helicobacter pylori eradication on serum hepcidin-25 level and iron parameters in patients with iron deficiency anemia

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dc.contributor.authorSapmaz, Ferdane
dc.contributor.authorBasyigit, Sebahat
dc.contributor.authorKalkan, Ismail Hakki
dc.contributor.authorKisa, Ucler
dc.contributor.authorKavak, Engin Eren
dc.contributor.authorGuliter, Sefa
dc.date.accessioned2020-06-25T18:16:36Z
dc.date.available2020-06-25T18:16:36Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810
dc.description.abstractThe aim of this study was to evaluate the efficacy of bismuth-based quadruple regiment as a first-line treatment for Helicobacter pylori (H. pylori) eradication in patients with unexplained iron deficiency anemia (IDA). The serum hepcidin-25, iron, ferritin levels and total iron-binding capacity were evaluated at baseline and after H. pylori eradication in order to assess whether H. pylori eradication plays a role in IDA related to H. pylori infection. The study included 80 patients with unexplained IDA and H. pylori infection. All patients received pantoprazole (40 mg b.i.d.), bismuth subcitrate (120 mg q.i.d.), tetracycline (500 mg q.i.d.) and metronidazole (500 mg t.i.d.) over 14 days as H. pylori eradication regimen. In all patients, blood samples were drawn at baseline and 1 month after eradication therapy. In all patients, serum hepcidin-25 levels were determined by using commercially available enzyme-linked immunosorbent assay kits. There was an improvement in hemoglobin, iron, total iron-binding capacity and ferritin values after H. pylori eradication in all subjects. Serum hepcidin-25 levels significantly decreased after H. pylori eradication (p < 0.001). Gastric H. pylori infection is a common cause of IDA of unknown origin in adult patients. Our results provide evidence indicating that hepcidin level decreases after successful H. pylori eradication with improvement in IDA.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00508-016-0961-5
dc.identifier.endpage340en_US
dc.identifier.issn0043-5325
dc.identifier.issn1613-7671
dc.identifier.issue9-10en_US
dc.identifier.pmid26932797
dc.identifier.scopus2-s2.0-84959421870
dc.identifier.scopusqualityQ1
dc.identifier.startpage335en_US
dc.identifier.urihttps://doi.org/10.1007/s00508-016-0961-5
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6573
dc.identifier.volume128en_US
dc.identifier.wosWOS:000376607300005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Wienen_US
dc.relation.ispartofWiener Klinische Wochenschrift
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe impact of Helicobacter pylori eradication on serum hepcidin-25 level and iron parameters in patients with iron deficiency anemiaen_US
dc.typeArticle

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