Effects of magnesium sulphate on the oxidative stress, biochemical and hematological parameters in pregnant rats with L- NAME induced preeclampsia
Yükleniyor...
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Parlar Scientific Publications (P S P)
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to investigate the effects of magnesium sulphate (MgSO4) on some biochemical and hematological parameters, lipid peroxidation, and antioxidant enzymes in pregnant rat model of preeclampsia induced by L-w-nitro-L-arginine methyl ester (L-NAME). Thirty two pregnant Sprague-Dawley rats were divided into 4 equal groups as control, L-NAME (50 mg/kg bw/day), MgSO4 (600 mg/kg bw/day) or L-NAME + MgSO4 (1-4) given groups on the 11(th) day of the pregnancy in their drinking water. The increased blood pressure (BP) was detected on the 12(th) and 19(th) days of pregnancy. Blood samples were collected on the 19(th) day to determine blood oxidative status, some biochemical and hematological parameters. L-NAME decreased erythrocyte superoxide dismutase activity, plasma total protein level and increased erythrocyte catalase and glutathion peroxidase activities, BP, plasma malondialdehyde, cholesterol and triglyceride levels, alkaline phophatase activity and white blood cell counts compared to control group. While MgSO4 decreased aspartate amino transferase and alanine amino transferase activities and calcium level, it increased magnesium level compared to control group. Increased BP, plasma cholesterol levels, erythrocyte catalase and glutathione peroxidase activities by L-NAME were decreased by the addition of MgSO4. In conclusion, MgSO4 (600 mg/kg bw/day) may be beneficial in the treatment of preeclampsia by increasing usage of antioxidant enzymes
Açıklama
Anahtar Kelimeler
Preeclampsia, L-NAME, magnesium sulphate, oxidative stress
Kaynak
Fresenius Environmental Bulletin
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
20
Sayı
8
Künye
closedAccess
