Effects of magnesium sulphate on the oxidative stress, biochemical and hematological parameters in pregnant rats with L- NAME induced preeclampsia

Basit Öğe Kaydı
dc.contributor.authorCinar, Miyase
dc.contributor.authorYildirim, Ebru
dc.contributor.authorYigit, A. Arzu
dc.contributor.authorMacun, H. Ceyhun
dc.contributor.authorDuru, Ozkan
dc.date.accessioned2020-06-25T17:52:07Z
dc.date.available2020-06-25T17:52:07Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe aim of this study was to investigate the effects of magnesium sulphate (MgSO4) on some biochemical and hematological parameters, lipid peroxidation, and antioxidant enzymes in pregnant rat model of preeclampsia induced by L-w-nitro-L-arginine methyl ester (L-NAME). Thirty two pregnant Sprague-Dawley rats were divided into 4 equal groups as control, L-NAME (50 mg/kg bw/day), MgSO4 (600 mg/kg bw/day) or L-NAME + MgSO4 (1-4) given groups on the 11(th) day of the pregnancy in their drinking water. The increased blood pressure (BP) was detected on the 12(th) and 19(th) days of pregnancy. Blood samples were collected on the 19(th) day to determine blood oxidative status, some biochemical and hematological parameters. L-NAME decreased erythrocyte superoxide dismutase activity, plasma total protein level and increased erythrocyte catalase and glutathion peroxidase activities, BP, plasma malondialdehyde, cholesterol and triglyceride levels, alkaline phophatase activity and white blood cell counts compared to control group. While MgSO4 decreased aspartate amino transferase and alanine amino transferase activities and calcium level, it increased magnesium level compared to control group. Increased BP, plasma cholesterol levels, erythrocyte catalase and glutathione peroxidase activities by L-NAME were decreased by the addition of MgSO4. In conclusion, MgSO4 (600 mg/kg bw/day) may be beneficial in the treatment of preeclampsia by increasing usage of antioxidant enzymesen_US
dc.description.sponsorshipKirikkale UniversityKirikkale University [2006/20]en_US
dc.description.sponsorshipThis research was supported by the Kirikkale University Research Fund, Project No: 2006/20.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage1948en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-80052385159
dc.identifier.scopusqualityN/A
dc.identifier.startpage1942en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5084
dc.identifier.volume20en_US
dc.identifier.wosWOS:000294318900011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreeclampsiaen_US
dc.subjectL-NAMEen_US
dc.subjectmagnesium sulphateen_US
dc.subjectoxidative stressen_US
dc.titleEffects of magnesium sulphate on the oxidative stress, biochemical and hematological parameters in pregnant rats with L- NAME induced preeclampsiaen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Effects of magnesium sulphate on the oxidative stress, biochemical and hematological parameters in pregnant rats with L- NAME induced preeclampsia.pdf
Boyut:
432.63 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu