The effect of hyperbaric oxygen treatment on the renal functions in septic rats: Relation to oxidative damage
Yükleniyor...
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose. To investigate the effects of hyperbaric oxygen (HBO) treatment on renal functions and damage in septic rats. Methods. The animals were divided into four groups, each containing ten animals: control, hyperbaric oxygen, sepsis, and sepsis/hyperbaric oxygen. One milliliter of saline containing live Escherichia coli cells (2.1 x 10(9)) was injected intraperitoneally to induce sepsis. The groups treated with HBO were given five sessions of 2 atmospheres absolute of 100% oxygen at intervals of 6 h. Blood, urine, and tissue samples were then collected, and the functional renal parameters, malondialdehyde (MDA) levels, and superoxide dismutase (SOD) and catalase activities were examined. Results. The reduced glomerular filtration rate and urine flow returned to normal levels after HBO treatment; however, the increase in fractionated sodium excretion continued. The increased MDA levels in the renal cortex and medulla also decreased to the level of the control group. In the sepsis group, both the SOD and catalase activities decreased in the renal cortex, while a reduction was observed only in the catalase activity in the medulla. The reduced enzyme activities significantly increased in the sepsis/hyperbaric oxygen group. Conclusion. HBO treatment has a beneficial effect on renal dysfunction in sepsis. The probable reason for this effect is the reduction in oxidative damage because of the increase in antioxidative capacity.
Açıklama
Oter, Sukru/0000-0002-3361-1313; KISA, Ucler/0000-0002-8131-6810
Anahtar Kelimeler
hyperbaric oxygen, kidney function, sepsis, oxidative damage, rat
Kaynak
Surgery Today
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
35
Sayı
8
Künye
closedAccess
