The effect of hyperbaric oxygen treatment on the renal functions in septic rats: Relation to oxidative damage

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dc.contributor.authorEdremitlioğlu, Mustafa
dc.contributor.authorKılıç, Dilek
dc.contributor.authorOter, Şükrü
dc.contributor.authorKısa, Üçler
dc.contributor.authorKorkmaz, Ahmet
dc.contributor.authorCoşkun, Ömer
dc.contributor.authorBedir, O
dc.date.accessioned2020-06-25T17:40:30Z
dc.date.available2020-06-25T17:40:30Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.descriptionOter, Sukru/0000-0002-3361-1313; KISA, Ucler/0000-0002-8131-6810
dc.description.abstractPurpose. To investigate the effects of hyperbaric oxygen (HBO) treatment on renal functions and damage in septic rats. Methods. The animals were divided into four groups, each containing ten animals: control, hyperbaric oxygen, sepsis, and sepsis/hyperbaric oxygen. One milliliter of saline containing live Escherichia coli cells (2.1 x 10(9)) was injected intraperitoneally to induce sepsis. The groups treated with HBO were given five sessions of 2 atmospheres absolute of 100% oxygen at intervals of 6 h. Blood, urine, and tissue samples were then collected, and the functional renal parameters, malondialdehyde (MDA) levels, and superoxide dismutase (SOD) and catalase activities were examined. Results. The reduced glomerular filtration rate and urine flow returned to normal levels after HBO treatment; however, the increase in fractionated sodium excretion continued. The increased MDA levels in the renal cortex and medulla also decreased to the level of the control group. In the sepsis group, both the SOD and catalase activities decreased in the renal cortex, while a reduction was observed only in the catalase activity in the medulla. The reduced enzyme activities significantly increased in the sepsis/hyperbaric oxygen group. Conclusion. HBO treatment has a beneficial effect on renal dysfunction in sepsis. The probable reason for this effect is the reduction in oxidative damage because of the increase in antioxidative capacity.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00595-004-3000-5
dc.identifier.endpage661en_US
dc.identifier.issn0941-1291
dc.identifier.issue8en_US
dc.identifier.pmid16034546
dc.identifier.scopus2-s2.0-22744447011
dc.identifier.scopusqualityQ1
dc.identifier.startpage653en_US
dc.identifier.urihttps://doi.org/10.1007/s00595-004-3000-5
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3465
dc.identifier.volume35en_US
dc.identifier.wosWOS:000230690700010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofSurgery Today
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthyperbaric oxygenen_US
dc.subjectkidney functionen_US
dc.subjectsepsisen_US
dc.subjectoxidative damageen_US
dc.subjectraten_US
dc.titleThe effect of hyperbaric oxygen treatment on the renal functions in septic rats: Relation to oxidative damageen_US
dc.typeArticle

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