Effects of Dietary Supplementation with Vitamin C and Vitamin E and Their Combination on Growth Performance, Some Biochemical Parameters, and Oxidative Stress Induced by Copper Toxicity in Broilers

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dc.contributor.authorCinar, Miyase
dc.contributor.authorYildirim, Ebru
dc.contributor.authorYigit, A. Arzu
dc.contributor.authorYalcinkaya, Ilkay
dc.contributor.authorDuru, Ozkan
dc.contributor.authorKisa, Ucler
dc.contributor.authorAtmaca, Nurgul
dc.date.accessioned2020-06-25T18:12:14Z
dc.date.available2020-06-25T18:12:14Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810;
dc.description.abstractThis study investigated effects of dietary supplementation with vitamin C, vitamin E on performance, biochemical parameters, and oxidative stress induced by copper toxicity in broilers. A total of 240, 1-day-old, broilers were assigned to eight groups with three replicates of 10 chicks each. The groups were fed on the following diets: control (basal diet), vitamin C (250 mg/kg diet), vitamin E (250 mg/kg diet), vitamin C + vitamin E (250 mg/kg + 250 mg/kg diet), and copper (300 mg/kg diet) alone or in combination with the corresponding vitamins. At the 6th week, the body weights of broilers were decreased in copper, copper + vitamin E, and copper + vitamin C + vitamin E groups compared to control. The feed conversion ratio was poor in copper group. Plasma aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase activities, iron, copper concentrations, and erythrocyte malondialdehyde were increased; plasma vitamin A and C concentrations and erythrocyte superoxide dismutase were decreased in copper group compared to control. Glutathione peroxidase, vitamin C, and iron levels were increased; aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and copper levels were decreased in copper + vitamin C group, while superoxide dismutase, glutathione peroxidase, and vitamin E concentrations were increased; aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase were decreased in copper with vitamin E group compared to copper group. The vitamin C concentrations were increased; copper, uric acid, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and malondialdehyde were decreased in copper + vitamin C + vitamin E group compared to copper group. To conclude, copper caused oxidative stress in broilers. The combination of vitamin C and vitamin E addition might alleviate the harmful effects of copper as demonstrated by decreased lipid peroxidation and hepatic enzymes.en_US
dc.description.sponsorshipKirikkale University Research FundKirikkale University [2008/40]en_US
dc.description.sponsorshipFinancial support for this Project (Project No. 2008/40) was provided by the Kirikkale University Research Fund.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s12011-014-9926-6
dc.identifier.endpage196en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2en_US
dc.identifier.pmid24615553
dc.identifier.scopus2-s2.0-84899628098
dc.identifier.scopusqualityQ1
dc.identifier.startpage186en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-014-9926-6
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5825
dc.identifier.volume158en_US
dc.identifier.wosWOS:000334500000008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCopperen_US
dc.subjectBiochemical parametersen_US
dc.subjectOxidative stressen_US
dc.subjectPerformanceen_US
dc.subjectVitamin Cen_US
dc.subjectVitamin Een_US
dc.titleEffects of Dietary Supplementation with Vitamin C and Vitamin E and Their Combination on Growth Performance, Some Biochemical Parameters, and Oxidative Stress Induced by Copper Toxicity in Broilersen_US
dc.typeArticle

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