Effect of overnight nasal continuous positive airway pressure treatment on the endothelial function in patients with obstructive sleep apnea

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dc.contributor.authorTulmac, Murat
dc.contributor.authorTireli, Emine
dc.contributor.authorEbinc, Haksun
dc.contributor.authorSimsek, Vedat
dc.contributor.authorDogru, Mehmet Tolga
dc.contributor.authorYildirim, Nesligul
dc.contributor.authorEkici, Mehmet Savas
dc.date.accessioned2020-06-25T17:52:29Z
dc.date.available2020-06-25T17:52:29Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810
dc.description.abstractObjective: In this prospective study, we aimed to investigate acute effect of nasal continuous positive airway pressure (CPAP) therapy on the endothelial function of patients with obstructive sleep apnea syndrome (OSA) by using brachial artery flow mediated dilatation (FMD) method. Methods: Newly diagnosed thirty OSA patients with ages between 29 and 72 years were included in this study. FMD and high sensitivity C-reactive protein (hsCRP) values of patients obtained before and after CPAP dose titration test were compared with paired samples t test or Wilcoxon signed ranks test. Results: With CPAP therapy apnea hypopnea indices were reduced (60.6 +/- 24.9/h vs. 9.6 +/- 7.9/h; p<0.001) and oxygen desaturation indices recovered (50 +/- 27/h vs. 6 +/- 7/h; p<0.001). Heart rates of patients decreased after CPAP therapy (80 +/- 10/min vs. 73 +/- 8/min; p=0.003). FMD values significantly increased after CPAP (8.55 +/- 5.82 percent vs. 12.08 +/- 7.17 percent; p=0.003). HsCRP values after CPAP were not different from baseline values Conclusion: Acute improvement of the endothelial function with one night CPAP therapy suggests endothelial dysfunction in OSA patients to be result of acute pathophysiologic factors. In intermediate and severe OSA patients, CPAP therapy may be considered in acute treatment of diseases associated with endothelial dysfunction. (Anadolu Kardiyol Derg 2012; 12: 560-5)en_US
dc.identifier.citationTulmaç M., Tireli E., Ebinç H., Şimşek V., Doğru M. T., Yıldırım N., Kısa Ü., Ekici M. S. (2012). Effect of overnight nasal continuous positive airway pressure treatment on the endothelial function in patients with obstructive sleep apnea. Anadolu Kardiyoloji Dergisi, 12(7), 560 - 565.en_US
dc.identifier.doi10.5152/akd.2012.181
dc.identifier.endpage565en_US
dc.identifier.issn1302-8723
dc.identifier.issue7en_US
dc.identifier.pmid22804976
dc.identifier.scopus2-s2.0-84868271385
dc.identifier.scopusqualityN/A
dc.identifier.startpage560en_US
dc.identifier.trdizinid145238
dc.identifier.urihttps://doi.org/10.5152/akd.2012.181
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5164
dc.identifier.volume12en_US
dc.identifier.wosWOS:000312740700012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves Yayinciliken_US
dc.relation.ispartofAnadolu Kardiyoloji Dergisi-The Anatolian Journal Of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndothelial dysfunctionen_US
dc.subjectobstructive sleep apneaen_US
dc.subjectcontinuous positive airway pressureen_US
dc.subjectC-reactive proteinen_US
dc.subjectflow mediated dilatationen_US
dc.titleEffect of overnight nasal continuous positive airway pressure treatment on the endothelial function in patients with obstructive sleep apneaen_US
dc.typeArticle

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