The Effect of Simvastatin on Pulmonary Damage in Experimental Peritonitis in Rats

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dc.contributor.authorAltunal, Çetin
dc.contributor.authorAğalar, Fatih
dc.contributor.authorAğalar, Canan
dc.contributor.authorDaphan, Çağatay
dc.contributor.authorSaygun, Oral
dc.contributor.authorAydınuraz, Kuzey
dc.contributor.authorDom, Sedat
dc.date.accessioned2020-06-25T18:12:36Z
dc.date.available2020-06-25T18:12:36Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionSahiner, Ibrahim Tayfun/0000-0002-3921-7675
dc.description.abstractStatins are widely used in the treatment of hyperlipidemia, as they inhibit cholesterol synthesis. They also have anti-inflammatory, antioxidant, immunomodulatory, and positive endothelial-functional effects. It is hypothesized that simvastatin ameliorates pulmonary damage secondary to peritonitis in rats. Forty Wistar albino rats were divided into four groups. In sham group, laparotomy was the standard procedure. In simvastatin group, simvastatin was given perorally before laparotomy. In sepsis group, peritoneal sepsis was constituted by cecal ligation and puncture technique. In sepsis+simvastatin group, the procedures of simvastatin and sepsis groups were applied together. After sacrification at the 72nd hour, tissue samples from lungs were harvested for histopathological examination, wet and dry weight measurements, and tissue culture, tissue malondialdehyde, and nitric oxide tests. Blood samples were taken for C-reactive protein and whole blood count. While the malondialdehyde levels were found to be significantly higher in sepsis group, nitric oxide levels were found to be significantly lower in simvastatin+sepsis group. Alveolar hemorrhage was highest in simvastatin+sepsis group. There was no difference for C-reactive protein, leukocyte levels, and histopathological examination between any groups. The ratios of wet and dry lung weights were higher in simvastatin-given groups. Simvastatin has no positive effect in terms of lung dysfunction on experimental sepsis model. For a better understanding of the effects of simvastatin on lung injury in peritoneal sepsis, experimental models of longer duration that enable to search the effects of simvastatin beyond 3 days will be more useful.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s12262-013-0845-0
dc.identifier.endpageS375en_US
dc.identifier.issn0972-2068
dc.identifier.issn0973-9793
dc.identifier.pmid26730028
dc.identifier.scopus2-s2.0-84873357159
dc.identifier.scopusqualityQ4
dc.identifier.startpageS370en_US
dc.identifier.urihttps://doi.org/10.1007/s12262-013-0845-0
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5978
dc.identifier.volume77en_US
dc.identifier.wosWOS:000368531700037
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal Of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSimvastatinen_US
dc.subjectHMG-CoA reductase inhibitoren_US
dc.subjectCecal ligation punctureen_US
dc.subjectMDAen_US
dc.subjectNOen_US
dc.titleThe Effect of Simvastatin on Pulmonary Damage in Experimental Peritonitis in Ratsen_US
dc.typeArticle

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