The Effects of Simvastatin on Ischemia Reperfusion Injury in an Experimental Colon Anastomosis Model
Yükleniyor...
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer India
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Anastomotic leakage is more frequently reported in colonic anastomoses. Ischemia reperfusion injury is one of the main reasons for anastomotic leakage. Simvastatin is known to prevent tissue damage induced by free oxygen radicals after ischemia reperfusion injury. The effect of simvastatin on colonic anastomosis impaired by ischemia reperfusion injury is investigated. Single layer, end-to-end colocolic anastomosis after 0.5-cm colon resection was performed in Wistar Albino rats. In Group 1 (control) (n= 10), colonic anastomosis without I-R was performed. In Group 2 (n = 10), the superior mesenteric artery was clamped for 10 min followed by 60 min of reperfusion after which resection anastomosis was performed. In Group 3 (n= 10), 10 mg/kg simvastatin was given by gavage for 7 days after I-R and resection anastomosis. In Group 4 (n = 10), the rats received 10 mg/kg simvastatin by gavage 7 days before and 7 days after ischemia reperfusion and surgery. All of the rats were sacrificed 8 days after surgery. Anastomotic bursting pressure and tissue hydroxyproline levels were measured. Postoperative administration of simvastatin restored the anastomotic bursting pressure and hydroxyproline levels to that of control group thus overcoming the effect of ischemia reperfusion injury. Simvastatin administered postoperatively in an experimental model of colonic resection anastomosis impaired by ischemia reperfusion injury increased anastomotic bursting pressures and tissue hydroxyproline levels. Further experimental and clinical studies will show whether administration of simvastatin will increase reliability of the anastomosis and decrease postoperative morbidity and mortality in colonic anastomosis after ischemia reperfusion injury.
Açıklama
KISA, Ucler/0000-0002-8131-6810; Aydin, Oktay/0000-0001-5728-0128
Anahtar Kelimeler
Superior mesenteric artery occlusion, Simvastatin, Colon, Anastomotic healing, Ischemia reperfusion, Rat
Kaynak
Indian Journal Of Surgery
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
79
Sayı
5
Künye
Akarsu, M., Saygun, O., Aydinuraz, K., Aydin, O., Daphan, C. E., Tanrıkulu, F. B., Kisa, U., & Comu, F. M. (2017). The Effects of Simvastatin on Ischemia Reperfusion Injury in an Experimental Colon Anastomosis Model. The Indian journal of surgery, 79(5), 390–395.
